Two hexapeptide and two tetrapeptide analogues of the bioactive hexapeptides [(Trp/Met/Phe)-Lys-Tyr-(Met/Val
)-(Pro/Val)-Met] have been synthesized by incorporating novel peptide isosteres such as 2-isoxazoline, (E)-alkene, and reduced amide isosteres. These immunomodulating hexapeptides are known to stimulate the formation of inositol phosphates in lymphocyte cell lines.
J. Young Lee, Y. Jun Chung, Y. Bae, S. Ho Ryu and B. Hyean Kim, J. Chem. Soc., Perkin Trans. 1, 1998, 359 DOI: 10.1039/A703660D
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