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A pharmacogenetic study of ABCB1 polymorphisms and cyclosporine treatment response in patients with psoriasis in the Greek population

Abstract

Psoriasis affects 2–3% of the population, causing significant morbidity and financial burden. Immunosuppressive drugs such as cyclosporine are first line systemic therapies for moderate-to-severe forms. However, patients exhibit heterogeneity in their response to therapy, possibly due to genetic factors. The aim of the present study was to assess the ABCB1 T-129C, G1199A, C1236T, G2677T and C3435T single-nucleotide polymorphisms (SNPs) as candidate predictive markers of response to cyclosporine treatment in 84 psoriasis patients. 62% of the patients were defined as responders and 38% as nonresponders. All SNPs complied with Hardy–Weinberg equilibrium. SNP and haplotype analyses were performed to access responsiveness to treatment. Association analysis revealed statistically significant association of SNP 3435 T with negative response (P=0.0075), a result that was further validated in haplotype analysis. This study is the first in the field of the pharmacogenetics of cyclosporine in psoriasis whose results merit further exploitation in larger independent cohorts.

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Acknowledgements

We are very grateful to all the participants of the study. This work was supported by the postgraduate programs ‘Biotechnology-Quality Assessment in Nutrition and the Environment’ and ‘Molecular Biology and Genetics Applications—Diagnostic Markers’ of the Department of Biochemistry and Biotechnology, University of Thessaly, Greece.

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Correspondence to Y Vasilopoulos.

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Vasilopoulos, Y., Sarri, C., Zafiriou, E. et al. A pharmacogenetic study of ABCB1 polymorphisms and cyclosporine treatment response in patients with psoriasis in the Greek population. Pharmacogenomics J 14, 523–525 (2014). https://doi.org/10.1038/tpj.2014.23

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  • DOI: https://doi.org/10.1038/tpj.2014.23

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