Abstract
Study design:
Case report of a severe upper cervical cord compression and tetraparesis by a massive cervical exostotic osteochondroma in a patient with multiple exostoses–mental retardation syndrome (Langer–Giedion syndrome; LGS).
Objective:
To describe this very rare pathological condition and the results of surgical intervention.
Setting:
Gifu, Japan.
Methods:
A 23-year-old man was referred to our clinic because of progressing tetraparesis. He had previously been diagnosed with hereditary multiple exostoses and mental retardation. As he had not complained of any symptoms, his family only noticed the tetraparesis after advanced deterioration. His face possessed the pathognomic features of LGS. A postmyelogram CT scan demonstrated an exostotic mass arising from the left-side C2 pedicle with associated severe spinal cord compression. He was diagnosed with LGS. Hemilaminectomy on the left side and resection of the osteochondroma were performed.
Results:
At 5 years postoperatively, a neurological examination showed the full return of all motor functions. The CT scan revealed no intracanalar recurrence of the tumor.
Conclusion:
In this case of severe tetraparesis due to cervical osteochondroma, decompression by hemilaminectomy provided excellent results. In patients with LGS and intracanalar osteochondroma, the neurological deficit may be masked by mental retardation. Hence, awareness of this pathological condition will help clinicians diagnose it at an early stage.
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Introduction
Hereditary multiple exostoses1 is a condition characterized by anomalous skeletal development with multiple exostotic osteochondromas frequently occurring from the metaphyseal regions of long bones, iliac crests, and scapulas. The vertebral column is involved in approximately 7% of patients with hereditary multiple exostoses.2 Several cases with the development of an osteochondroma in the spinal canal, hereafter referred to as intracanalar osteochondroma, and spinal cord compression have been reported as relatively rare pathological conditions.3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
Multiple exostoses are also a cardinal feature of trichorhinophalangeal syndrome (TRP) type II (Langer–Giedion syndrome),14 which includes mental retardation and peculiar facial features.14, 15, 16, 17, 18, 19, 20 We report a very rare case of tetraparesis, due to an intracanalar osteochondroma at the upper cervical spine in a patient with Langer–Giedion syndrome (LGS), which was successfully treated by surgery. This is the first case report of spinal exostotic osteochondroma and spinal cord compression associated with LGS in the literature.
Case report
A 23-year-old man was admitted to our department in January 1998 for tetraparesis. Two months before, he became unable to walk after a gradual decline. During his childhood, he had absence epilepsy. Multiple bony deformities were noted since he was 9 years old. He was mentally retarded. His father had bony prominences in his ankles, although the details were not known. As he had not complained of the motor disturbances, his family only noticed his condition after it had deteriorated.
On admission, his height was 158 cm and his head was relatively small. His face (Figure 1) was unusual with large, laterally protruded ears, an elongated philtrum, thin upper lip, teeth malformations, and heavy eyebrows. Bony tumors were palpated at the occipital lesion and in the peri-articular areas of the upper and lower extremities. There was percussion pain at the midline of the upper cervical spine. Hyperelasticity of the skin and joint laxity was not observed. His IQ measured 42 and he had a marked disturbance in his speech.
The neurological examination disclosed spastic tetraparesis, with his manual muscle test at grade two to three below the bilateral C4 level. Sensory disturbances were present in the right hand. In addition, hyper-reflexia and pathological reflexes of the lower extremities and urinary incontinence were noted. Since his fine motor abilities in his fingers were remarkably deteriorated, he could not use chopsticks or other eating utensils with his hands.
Radiological studies disclosed numerous exostoses at the distal ends of the bilateral humeri, radii, ulnae, femurs, tibiae, fibulae, and metatarsal bones, as well as the occiput and the right-side sacroiliac joint. On plain X-ray film of the hands (Figure 2), cone-shaped epiphyses were demonstrated at the proximal phalanges of the fingers. Plain X-ray film of the cervical spine (Figure 3) showed irregular sclerotic changes at C2–C3. Myelography demonstrated a complete block of cerebrospinal fluid at the second cervical level. A postmyelogram CT scan (Figure 4) demonstrated an exostotic mass arising from the left-side C2 pedicle that severely compressed the spinal cord. The diagnosis was upper cervical cord compression due to exostotic osteochondroma at C2 with associated LGS. Because the tetraparesis was progressing, we indicated a surgical treatment for him.
Surgical treatment
At 1 month after his admission, a hemilaminectomy was performed, using an air-drill, on the left side from the inferior half of C1 to the superior half of C3. The muscles attaching to the spinosus processus of the C2, such as semispinalis cervicis, were preserved. The intracanalar portion of the tumor compressing the spinal cord was then resected. We did not resect the anterior part of the tumor, which would have required an anterior or lateral approach.
The histological examination of the tumor specimen revealed the typical characteristics of osteochondroma with a thick cartilage cap. The postoperative CT scan (Figure 5) showed sufficient decompression. Spastic tetraparesis improved gradually and the patient regained the ability to walk without a cane 2 months after the operation. At 5 years postoperatively, plain X-ray film of the cervical spine showed no sign of subsequent kyphosis or instability. The CT scan (Figure 6) did not reveal intracanalar recurrence of the tumor, but there was further growth of the anterior residual mass. An approval for reporting this illness including the features of appearance to the scientific literature was obtained from the patient.
Discussion
LGS,14 characterized by the combination of multiple exostoses and mental retardation,14, 15, 16, 17, 18, 19, 20 is a very rare contiguous gene-deletion syndrome21 caused by the simultaneous deletion of the EXT1 and TRPS1 genes on choromosome 8q24.22 The characteristics of the present patient, including multiple exostoses, mental retardation, short stature, small head, unusual facial appearance, and cone-shaped epiphyses of the hands, sufficiently fulfilled all the major criteria of this disease,14, 19, 20 except for a bulbous nose. Recently, patients with clinical features very similar to LGS, but with epilepsy, were reported by two authors23, 24 as a different criteria from LGS. The lack of a chromosome analysis and the past history of epilepsy in this patient make a definite diagnosis difficult. In any case, the combination of multiple exostoses, mental retardation, and tetraparesis due to intracanalar osteochondroma has not been previously reported in the literature.
Surgical treatments have been indicated for intracanalar osteochondroma, which is associated with myelopathy,2, 3, 4, 5, 6, 7, 12, 13 radiculopathy,8 insufficiency of the vertebral artery,25 and neck pain.2 From various other possible surgical procedures, laminectomy was chosen by a majority of authors.2, 3, 4, 5, 6 Then, to avoid the risk of postlaminectomy kyphosis26, 27 and subsequent instability26 as complications of laminectomy for the cervical spine, the use of posterior stabilization and posterolateral fusion,7 anterior stabilization and fusion,9 and laminoplasty12 were reported. As a less invasive procedure, we chose hemilaminectomy28 for this patient. The excision of the intracanalar portion of the tumor was successfully performed and neurological recovery at the 5-year follow-up was excellent without subsequent problems. However, as we did not resect the anterior part of the tumor, it manifested growth at the 5-year follow-up. Taking into account the incidence of malignant transformation of the exostoses in hereditary multiple exostosis,29 this patient requires careful monitoring and further therapeutic treatments should be considered.
The clinically important lesson from this patient with LGS is that his tetraparesis was not recognized, presumably because of his mental retardation, until it became severe. Indeed, his intracanalar tumor is among the largest described in the literature. Awareness of this pathological condition would help clinicians make an early and correct diagnosis.
Conclusion
We reported a case of severe upper cervical cord compression and tetraparesis by a massive cervical exostotic osteochondroma in a patient with multiple exostoses–mental retardation syndrome (LGS). For this case of severe tetraparesis, decompression by hemilaminectomy provided an excellent result.
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Miyamoto, K., Sakaguchi, Y., Hosoe, H. et al. Tetraparesis due to exostotic osteochondroma at upper cervical cord in a patient with multiple exostoses–mental retardation syndrome (Langer–Giedion syndrome). Spinal Cord 43, 190–194 (2005). https://doi.org/10.1038/sj.sc.3101690
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DOI: https://doi.org/10.1038/sj.sc.3101690
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