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Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

Oncogene volume 24, pages 6005–6015 (2005)Cite this article

Abstract

Over the past 25 years, animal models of human T-lymphotropic virus type 1 (HTLV-1) infection and transformation have provided critical knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL). The virus consistently infects rabbits, some non-human primates, and to a lesser extent rats. In addition to providing fundamental concepts in viral transmission and immune responses against HTLV-1 infection, these models have provided new information about the role of viral proteins in carcinogenesis. Mice and rats, in particular immunodeficient strains, are useful models to assess immunologic parameters mediating tumor outgrowth and therapeutic invention strategies against lymphoma. Genetically altered mice including both transgenic and knockout mice offer important models to test the role of specific viral and host genes in the development of HTLV-1-associated lymphoma. Novel approaches in genetic manipulation of both HTLV-1 and animal models are available to address the complex questions that remain about viral-mediated mechanisms of cell transformation and disease. Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma

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Acknowledgements

This work was supported by National Institute of Health grants RR-14324 and CA-100730 awarded to Dr Michael Lairmore and CA-70529 and CA-09338 awarded through the Ohio State University Comprehensive Cancer Center.

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  1. Lee Silverman: Millennium Pharmaceuticals Inc., Cambridge, MA, USA

Authors and Affiliations

  1. Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, 43210-1093, OH, USA

    Michael D Lairmore & Lee Silverman

  2. Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, 43210-1093, OH, USA

    Michael D Lairmore

  3. Comprehensive Cancer Center, The Arthur G James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, 43210-1093, OH, USA

    Michael D Lairmore

  4. Department of Medicine, Division of Biology and Biological Sciences, Pathology, and Molecular Microbiology, Campus Box 8069, 660 S. Euclid Ave., Washington University School of Medicine, St Louis, 63110-1093, MO, USA

    Lee Ratner

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  1. Michael D Lairmore
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  2. Lee Silverman
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  3. Lee Ratner
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Correspondence to Michael D Lairmore.

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Lairmore, M., Silverman, L. & Ratner, L. Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation. Oncogene 24, 6005–6015 (2005). https://doi.org/10.1038/sj.onc.1208974

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