Abstract
The cell cycle behavior of hematopoietic cells varies from extended quiescence to spectacular proliferation. Cell cycle regulators choreograph these transitions through variation in the makeup of cyclin-dependent kinase (cdk)-containing complexes and through alteration in protein expression levels and subcellular localization. The mechanisms through which cell cycle regulators couple proliferation, differentiation and survival is coming into sharper focus. Cdk-inhibitors, once thought of solely in terms of a checkpoint function on cycling, are now known to interact directly with proteins and pathways central to differentiation and apoptosis. By shuttling between binding partners committed to discrete functional pathways, cell cycle regulators may directly coordinate proliferation with differentiation, migration and apoptosis.
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References
Adachi M, Roussel MF, Havenith K, Sherr CJ . 1997 Blood 90: 126–137
Amanullah A, Hoffman B, Liebermann DA . 2000 Blood 96: 475–482
Ando K, Ajchenbaum-Cymbalista F, Griffin JD . 1993 Proc. Natl. Acad. Sci. USA 90: 9571–9575
Ando K, Griffin JD . 1995 Oncogene 10: 751–755
Asada M, Yamada T, Ichijo H, Delia D, Miyazono K, Fukumuro K, Mizutani S . 1999 EMBO J. 18: 1223–1234
Balomenos D, Martin-Caballero J, Garcia MI, Prieto I, Flores JM, Serrano M, Martinez AC . 2000 Nat. Med. 6: 171–176
Bellido T, O'Brien CA, Roberson PK, Manolagas SC . 1998 J. Biol. Chem. 273: 21137–21144
Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT . 1995 Science 267: 104–108
Bradford GB, Williams B, Rossi R, Bertoncello I . 1997 Exp. Hematol. 25: 445–453
Braun SE, Mantel C, Rosenthal M, Cooper S, Liu L, Robertson KA, Hromas R, Broxmeyer HE . 1998 Blood Cells Mol. Dis. 24: 138–148
Bromleigh VC, Freedman LP . 2000 Genes Dev. 14: 2581–2586
Burger C, Wick M, Muller R . 1994 J. Cell Sci. 107: 2047–2054
Capel B, Hawley RG, Mintz B . 1990 Blood 75: 2267–2270
Casini T, Pelicci PG . 1999 Oncogene 18: 3235–3243
Caslini C, Shilatifard A, Yang L, Hess JL . 2000 Proc. Natl. Acad. Sci. USA 97: 2797–2802
Chen G, Lee EY . 1999 DNA Cell Biol. 18: 305–314
Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, Roberts JM, Sherr CJ . 1999 EMBO J. 18: 1571–1583
Cheng T, Rodrigues N, Dombkowski D, Stier S, Scadden DT . 2000a Nat. Med. 6: 1235–1240
Cheng T, Rodrigues N, Shen H, Yang Y, Dombkowski D, Sykes M, Scadden DT . 2000b Science 287: 1804–1808
Cheshier SH, Morrison SJ, Liao X, Weissman IL . 1999 Proc. Natl. Acad. Sci. USA 96: 3120–3125
Coats S, Whyte P, Fero ML, Lacy S, Chung G, Randel E, Firpo E, Roberts JM . 1999 Curr. Biol. 9: 163–173
Coqueret O, Gascan H . 2000 J. Biol. Chem. 275: 18794–18800
Crescenzi M, Soddu S, Tato F . 1995 J. Cell Physiol. 162: 26–35
Dai MS, Mantel CR, Xia ZB, Broxmeyer HE, Lu L . 2000 Blood 96: 3985–3987
Dao MA, Taylor N, Nolta JA . 1998 Proc. Natl. Acad. Sci. USA 95: 13006–13011
Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang XF . 1995 Proc. Natl. Acad. Sci. USA 92: 5545–5549
de Koning JP, Soede-Bobok AA, Ward AC, Schelen AM, Antonissen C, van Leeuwen D, Lowenberg B, Touw IP . 2000 Oncogene 19: 3290–3298
Decesse JT, Medjkane S, Datto MB, Cremisi CE . 2001 Oncogene 20: 962–971
Delavaine L, La Thangue NB . 1999 Oncogene 18: 5381–5392
Della Ragione F, Borriello A, Mastropietro S, Della Pietra V, Monno F, Gabutti V, Locatelli F, Bonsi L, Bagnara GP, Iolascon A . 1997 Biochem. Biophys. Res. Commun 231: 73–76
Deng C, Zhang P, Harper JW, Elledge SJ, Leder P . 1995 Cell 82: 675–684
Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, Seth PK, Dotto GP . 1998 Science 280: 1069–1072
Dijkers PF, Medema RH, Pals C, Banerji L, Thomas NS, Lam EW, Burgering BM, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ . 2000 Mol. Cell. Biol 20: 9138–9148
Dimri GP, Nakanishi M, Desprez PY, Smith JR, Campisi J . 1996 Mol. Cell. Biol 16: 2987–2997
Duarte RF, Frank DA . 2000 Blood 96: 3422–3430
Ducos K, Panterne B, Fortunel N, Hatzfeld A, Monier MN, Hatzfeld J . 2000 J. Cell Physiol. 184: 80–85
Eaves CJ, Cashman JD, Kay RJ, Dougherty GJ, Otsuka T, Gaboury LA, Hogge DE, Lansdorp PM, Eaves AC, Humphries RK . 1991 Blood 78: 110–117
Ellisen LW, Carlesso N, Cheng T, Scadden DT, Haber DA . 2001 EMBO J. 20: 1897–1909
Englert C, Maheswaran S, Garvin AJ, Kreidberg J, Haber DA . 1997 Cancer Res. 57: 1429–1434
Estanyol JM, Jaumot M, Casanovas O, Rodriguez-Vilarrupla A, Agell N, Bachs O . 1999 J. Biol. Chem. 274: 33161–33165
Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM . 1996 Cell 85: 733–744
Fortunel N, Hatzfeld J, Kisselev S, Monier MN, Ducos K, Cardoso A, Batard P, Hatzfeld A . 2000a Stem Cells 18: 102–111
Fortunel NO, Hatzfeld A, Hatzfeld JA . 2000b Blood 96: 2022–2036
Franklin DS, Xiong Y . 1996 Mol. Biol. Cell. 7: 1587–1599
Freemerman AJ, Vrana JA, Tombes RM, Jiang H, Chellappan SP, Fisher PB, Grant S . 1997 Leukemia 11: 504–513
Fukada T, Ohtani T, Yoshida Y, Shirogane T, Nishida K, Nakajima K, Hibi M, Hirano T . 1998 EMBO J. 17: 6670–6677
Furukawa Y, Kikuchi J, Nakamura M, Iwase S, Yamada H, Matsuda M . 2000 Br. J. Haematol. 110: 663–673
Gartel AL, Goufman E, Tevosian SG, Shih H, Yee AS, Tyner AL . 1998 Oncogene 17: 3463–3469
Glimm H, Eaves CJ . 1999 Blood 94: 2161–2168
Glimm H, Oh IH, Eaves CJ . 2000 Blood 96: 4185–4193
Gonze D, Goldbeter A . 2001 J. Theor. Biol. 210: 167–186
Gothot A, Pyatt R, McMahel J, Rice S, Srour EF . 1997 Blood 90: 4384–4393
Gothot A, Pyatt R, McMahel J, Rice S, Srour EF . 1998a Exp. Hematol. 26: 562–570
Gothot A, van der Loo JC, Clapp DW, Srour EF . 1998b Blood 92: 2641–2649
Grana X, Garriga J, Mayol X . 1998 Oncogene 17: 3365–3383
Harris TE, Albrecht JH, Nakanishi M, Darlington GJ . 2001 J. Biol. Chem. 276: 29200–29209
Hatzfeld J, Li ML, Brown EL, Sookdeo H, Levesque JP, O'Toole T, Gurney C, Clark SC, Hatzfeld A . 1991 J. Exp. Med. 174: 925–929
Hoshikawa Y, Amimoto K, Mizuguchi R, Hatakeyama M . 1998 Anal. Biochem. 261: 211–218
Hsieh FF, Barnett LA, Green WF, Freedman K, Matushansky I, Skoultchi AI, Kelley LL . 2000 Blood 96: 2746–2754
Jiang H, Lin J, Su ZZ, Collart FR, Huberman E, Fisher PB . 1994 Oncogene 9: 3397–3406
Jordan JD, Landau EM, Iyengar R . 2000 Cell 103: 193–200
Josefsen D, Myklebust JH, Lomo J, Sioud M, Blomhoff HK, Smeland EB . 2000 Stem Cells 18: 261–272
Karanu FN, Murdoch B, Miyabayashi T, Ohno M, Koremoto M, Gallacher L, Wu D, Itoh A, Sakano S, Bhatia M . 2001 Blood 97: 1960–1967
Kato JY, Sherr CJ . 1993 Proc. Natl. Acad. Sci. USA 90: 11513–11517
Kiyokawa H, Richon VM, Venta-Perez G, Rifkind RA, Marks PA . 1993 Proc. Natl. Acad. Sci. USA 90: 6746–6750
LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E . 1997 Genes Dev. 11: 847–862
Leemhuis T, Yoder MC, Grigsby S, Aguero B, Eder P, Srour EF . 1996 Exp. Hematol. 24: 1215–1224
Lessard J, Schumacher A, Thorsteinsdottir U, van Lohuizen M, Magnuson T, Sauvageau G . 1999 Genes Dev. 13: 2691–2703
Li R, Waga S, Hannon GJ, Beach D, Stillman B . 1994 Nature 371: 534–537
Liu M, Lee MH, Cohen M, Bommakanti M, Freedman LP . 1996 Genes Dev. 10: 142–153
Lutterbach B, Westerdorf JJ, Linggi B, Isaac S, Seto E, Hiebert SW . 2000 J. Biol. Chem. 275: 651–656
Mahmud N, Devine SM, Weller KP, Parmar S, Sturgeon C, Nelson MC, Hewett T, Hoffman R . 2001 Blood 97: 3061–3068
Mantel C, Luo Z, Canfield J, Braun S, Deng C, Broxmeyer HE . 1996 Blood 88: 3710–3719
Marone M, Pierelli L, Mozzetti S, Masciullo V, Bonanno G, Morosetti R, Rutella S, Battaglia A, Rumi C, Mancuso S, Leone G, Giordano A, Scambia G . 2000 Br. J. Haematol. 110: 654–662
Matsumura I, Ishikawa J, Nakajima K, Oritani K, Tomiyama Y, Miyagawa J, Kato T, Miyazaki H, Matsuzawa Y, Kanakura Y . 1997 Mol. Cell. Biol. 17: 2933–2943
Matushansky I, Radparvar F, Skoultchi AI . 2000a Blood 96: 2755–2764
Matushansky I, Radparvar F, Skoultchi AI . 2000b Proc. Natl. Acad. Sci. USA 97: 14317–14322
Mayol X, Garriga J, Grana X . 1996 Oncogene 13: 237–246
Mayol X, Grana X . 1997 Prog. Cell Cycle Res. 3: 157–169
McDonald III ER, Wu GS, Waldman T, El-Deiry WS . 1996 Cancer Res. 56: 2250–2255
McLemore ML, Grewal S, Liu F, Archambault A, Poursine-Laurent J, Haug J, Link DC . 2001 Immunity 14: 193–204
Meiyanto E, Hoshijima M, Ogawa T, Ishida N, Takeya T . 2001 Biochem. Biophys. Res. Commun 282: 278–283
Mori A, Higashi H, Hoshikawa Y, Imamura M, Asaka M, Hatakeyama M . 1999 Oncogene 18: 6209–6221
Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL . 1996 Nat. Med. 2: 1011–1016
Morrison SJ, Weissman IL . 1994 Immunity 1: 661–673
Muller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, Prosperini E, Vigo E, Oliner JD, Helin K . 2001 Genes Dev. 15: 267–285
Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, Becker-Hapak M, Ezhevsky SA, Dowdy SF . 1998 Nat. Med. 4: 1449–1452
Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, Kitagawa M, Hatakeyama S . 2000 EMBO J. 19: 2069–2081
Okada S, Fukuda T, Inada K, Tokuhisa T . 1999 Blood 93: 816–825
Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M . 1995 Science 269: 682–685
Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ . 1995 Science 267: 1024–1027
Phelps DE, Xiong Y . 1998 Cell Growth Differ. 9: 595–610
Phillips RL, Ernst RE, Brunk B, Ivanova N, Mahan MA, Deanehan JK, Moore KA, Overton GC, Lemischka IR . 2000 Science 288: 1635–1640
Pietrzyk ME, Priestley GV, Wolf NS . 1985 Blood 66: 1460–1462
Podust VN, Brownell JE, Gladysheva TB, Luo RS, Wang C, Coggins MB, Pierce JW, Lightcap ES, Chau V . 2000 Proc. Natl. Acad. Sci. USA 97: 4579–4584
Rangarajan A, Talora C, Okuyama R, Nicolas M, Mammucari C, Oh H, Aster JC, Krishna S, Metzger D, Chambon P, Miele L, Aguet M, Radtke F, Dotto GP . 2001 EMBO J. 20: 3427–3436
Reid S, Broxmeyer HE . 1999 Cytokines Cell. Mol. Ther. 5: 129–138
Reynisdottir I, Massague J . 1997 Genes Dev. 11: 492–503
Romond PC, Rustici M, Gonze D, Goldbeter A . 1999 Ann. NY Acad. Sci. 879: 180–193
Schneider JW, Gu W, Zhu L, Mahdavi V, Nadal-Ginard B . 1994 Science 264: 1467–1471
Sherr CJ . 1994 Stem Cells 12: 47–55 discussion 55–57
Shimizu T, Awai N, Takeda K . 2000 Oncogene 19: 4640–4646
Shiyanov P, Bagchi S, Adami G, Kokontis J, Hay N, Arroyo M, Morozov A, Raychaudhuri P . 1996 Mol. Cell. Biol 16: 737–744
Snowden AW, Anderson LA, Webster GA, Perkins ND . 2000 Mol. Cell. Biol 20: 2676–2686
Sriuranpong V, Borges MW, Ravi RK, Arnold DR, Nelkin BD, Baylin SB, Ball DW . 2001 Cancer Res. 61: 3200–3205
Srour EF . 2000 Blood 96: 1609–1612
Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA, el-Houseini ME . 1994 Oncogene 9: 3389–3396
Steinman RA, Huang J, Yaroslavskiy B, Goff JP, Ball ED, Nguyen A . 1998 Blood 91: 4531–4542
Steinman RA, Johnson DE . 2000 Mol. Med. 6: 736–749
Steinman RA, Yaroslavskiy B, Goff JP, Watkins SC . 1997 Blood 90: 164a
Steinman RA, Yaroslavskiy B, Kaplan SS, Goff JP, Shields DS . 2000 Leuk. Res. 24: 601–610
Suzuki A, Tsutomi Y, Yamamoto N, Shibutani T, Akahane K . 1999 Mol. Cell. Biol 19: 3842–3847
Tamir A, Petrocelli T, Stetler K, Chu W, Howard J, Croix BS, Slingerland J, Ben-David Y . 2000 Cell Growth Differ. 11: 269–277
Taniguchi T, Endo H, Chikatsu N, Uchimaru K, Asano S, Fujita T, Nakahata T, Motokura T . 1999 Blood 93: 4167–4178
Thorsteinsdottir U, Sauvageau G, Humphries RK . 1999 Blood 94: 2605–2612
Tian JQ, Quaroni A . 1999a Am. J. Physiol. 276: G1094–G1104
Tian JQ, Quaroni A . 1999b Am. J. Physiol. 276: C1245–C1258
Timchenko NA, Wilde M, Nakanishi M, Smith JR, Darlington GJ . 1996 Genes Dev. 10: 804–815
Tong B, Grimes HL, Yang TY, Bear SE, Qin Z, Du K, El-Deiry WS, Tsichlis PN . 1998 Mol. Cell. Biol 18: 2462–2473
Tsukiyama T, Ishida N, Shirane M, Minamishima YA, Hatakeyama S, Kitagawa M, Nakayama K . 2001 J. Immunol. 166: 304–312
Vairo G, Livingston DM, Ginsberg D . 1995 Genes Dev. 9: 869–881
Vairo G, Soos TJ, Upton TM, Zalvide J, DeCaprio JA, Ewen ME, Koff A, Adams JM . 2000 Mol. Cell. Biol 20: 4745–4753
Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, Bakkour S, Pear WS, Bernstein ID . 2000 Nat. Med. 6: 1278–1281
Wang X, Scott E, Sawyers CL, Friedman AD . 1999 Blood 94: 560–571
Wilpshaar J, Falkenburg JH, Tong X, Noort WA, Breese R, Heilman D, Kanhai H, Orschell-Traycoff CM, Srour EF . 2000 Blood 96: 2100–2107
Yang W, Shen J, Wu M, Arsura M, FitzGerald M, Suldan Z, Kim DW, Hofmann CS, Pianetti S, Romieu-Mourez R, Freedman LP, Sonenshein GE . 2001 Oncogene 20: 1688–1702
Yaroslavskiy B, Watkins S, Donnenberg AD, Patton TJ, Steinman RA . 1999 Blood 93: 2907–2917
Yaroslavskiy BB, Watkins SC, Alber S, Steinman RA . 2001 J. Cell. Biochem. 83: 380–389
Yen A, Forbes ME . 1990 Cancer Res. 50: 1411–1420
Zezula J, Casaccia-Bonnefil P, Ezhevsky SA, Osterhout DJ, Levine JM, Dowdy SF, Chao MV, Koff A . 2001 EMBO Rep. 2: 27–34
Zhou P, Yao Y, Soh JW, Weinstein IB . 1999 Anticancer Res. 19: 4935–4945
Acknowledgements
The author would like to thank Daniel Johnson for critical review of the manuscript. This work was supported in part by grants HL65172 from NIH and 6111-99 from the Leukemia and Lymphoma Society to RA Steinman.
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Steinman, R. Cell cycle regulators and hematopoiesis. Oncogene 21, 3403–3413 (2002). https://doi.org/10.1038/sj.onc.1205325
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