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Sequence and functional properties of Ets genes in the model organism Drosophila

Oncogene volume 19, pages 6409–6416 (2000)Cite this article

Abstract

Detailed molecular and genetic studies, coupled with the recent sequencing of the fly genome, have identified eight Ets-related genes in the model organism Drosophila. All show homology to genes in vertebrate species. Functional analyses of some of the Drosophila ets genes have revealed their essential roles in developmental processes such as metamorphosis, oogenesis, neurogenesis, myogenesis, and eye development. Such studies have yielded important insights into our understanding of the genetic control of hormonally-regulated gene expression, programmed cell death, and signal transduction during cell fate determination and differentiation. The developmental roles of E74 (ELF1), pointed (Ets 1), yan (TEL), and D-elg (GABPα) will be reviewed in this article. The context of their participation in signal transduction and gene regulation will also be discussed. The information should be of significant value to the study of related processes in higher organisms due to the growing evidence for the cross species conservation of developmental mechanisms.

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Acknowledgements

This review is dedicated to the memory of Dr Takis S Papas whom we remember as a valued scientific educator and leader during our careers. He served as an insightful and influential PhD thesis advisor to RA Schulz and an unwavering career mentor to T Hsu.

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Authors and Affiliations

  1. Center for Molecular and Structural Biology, Hollings Cancer Center, and Department of Cell Biology and Anatomy, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, South Carolina, USA

    Tien Hsu

  2. Department of Biochemistry and Molecular Biology, Program in Genes & Development, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, Texas, USA

    Robert A Schulz

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  1. Tien Hsu
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Hsu, T., Schulz, R. Sequence and functional properties of Ets genes in the model organism Drosophila. Oncogene 19, 6409–6416 (2000). https://doi.org/10.1038/sj.onc.1204033

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