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  • Original Paper
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Control of apoptosis by Rel/NF-κB transcription factors

Abstract

Apoptosis is a physiological process critical for organ development, tissue homeostasis, and elimination of defective or potentially dangerous cells in complex organisms. Apoptosis can be initiated by a wide variety of stimuli, which activate a cell suicide program that is constitutively present in most vertebrate cells. In diverse cell types, Rel/NF-κB transcription factors have been shown to have a role in regulating the apoptotic program, either as essential for the induction of apoptosis or, perhaps more commonly, as blockers of apoptosis. Whether Rel/NF-κB promotes or inhibits apoptosis appears to depend on the specific cell type and the type of inducer. An understanding of the role of Rel/NF-κB transcription factors in controlling apoptosis may lead to the development of therapeutics for a wide variety of human diseases, including neurodegenerative and immune diseases, and cancer.

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Acknowledgements

We thank Marcello Arsura, Gail Sonenshein, and members of our laboratory for critical reading of the manuscript. We also thank Danny Khoury and Danielle Khoury for help in collecting information for this manuscript. Our work on Rel/NF-κB transcription factors and apoptosis was supported by National Institutes of Health grant CA47763 from the National Cancer Institute and a grant from the Council for Tobacco Research (both to TDG). MB was partially supported by NIH Training Grant in Molecular Biophysics TG32-GM08921.

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Barkett, M., Gilmore, T. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 18, 6910–6924 (1999). https://doi.org/10.1038/sj.onc.1203238

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