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  • Original Research Article
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The Multi-Source Interference Task: validation study with fMRI in individual subjects

Abstract

Dorsal anterior cingulate cortex (dACC) plays critical roles in cognitive processing, but group-averaging techniques have generally been required to obtain significant dACC activation in functional neuroimaging studies. Development of a task that reliably and robustly activates dACC within individuals is needed to improve imaging studies of neuropsychiatric disorders and localization of dACC in normal volunteers. By combining sources of cognitive interference (Stroop, Eriksen and Simon) with factors known to increase dACC activity, the Multi-Source Interference Task (MSIT) maximally taxes dACC, making it possible to reliably activate dACC within individuals using functional magnetic resonance imaging (fMRI). In this study, eight normal adult volunteers performed the MSIT during fMRI. We compared fMRI responses and performance data between interference and control trials. Significant dACC activation (P<1.7×10−4) was observed in all eight individuals and in the group-averaged fMRI data. In addition to dACC activation, group data also showed activation of presumably networked regions including dorsolateral prefrontal, premotor, and parietal cortices. The MSIT's reaction time interference effect (overall mean 312±61 ms) was up to 10 times greater than that of its component predecessors and temporally stable over hundreds of trials. The robustness, reliability and stability of the neuroimaging and performance data should make the MSIT a useful task with which to study normal human cognition and psychiatric pathophysiology.

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References

  1. Bush G, Frazier JA, Rauch SL, Seidman LJ, Whalen PJ, Jenike MA et al. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop. Biol Psychiatry 1999; 45: 1542–1552.

    CAS  PubMed  Google Scholar 

  2. Swanson J, Castellanos FX, Murias M, LaHoste G, Kennedy J . Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder. Curr Opin Neurobiol 1998; 8: 263–271.

    CAS  PubMed  Google Scholar 

  3. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 1999; 156: 675–682.

    CAS  PubMed  Google Scholar 

  4. Drevets WC . Neuroimaging studies of mood disorders. Biol Psychiatry 2000; 48: 813–829.

    CAS  PubMed  Google Scholar 

  5. George MS, Ketter TA, Parekh PI, Rosinsky N, Ring HA, Pazzaglia PJ et al. Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop). J Neuropsychiatry Clin Neurosci 1997; 9: 55–63.

    CAS  PubMed  Google Scholar 

  6. Carter CS, MacDonald 3rd AW, Ross LL, Stenger VA . Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: an event-related fMRI study. Am J Psychiatry 2001; 158: 1423–1428.

    CAS  PubMed  Google Scholar 

  7. Kiehl KA, Liddle PF . An event-related functional magnetic resonance imaging study of an auditory oddball task in schizophrenia. Schizophr Res 2001; 48: 159–171.

    CAS  PubMed  Google Scholar 

  8. Vogt BA, Vogt LJ, Nimchinsky EA, Hof PR . Primate cingulate cortex chemoarchitecture and its disruption in Alzheimer's disease. In: Bloom FE, Bjorklund A, Hokfelt T (Eds.) Handbook of Chemical Neuroanatomy, The Primate Nervous System. Amsterdam: Elsevier, 1997, pp 455–528.

    Google Scholar 

  9. Simpson Jr JR, Drevets WC, Snyder AZ, Gusnard DA, Raichle ME . Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety. Proc Natl Acad Sci USA 2001; 98: 688–693.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Whalen PJ, Bush G, McNally RJ, Wilhelm S, McInerney SC, Jenike MA et al. The emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division. Biol Psychiatry 1998; 44: 1219–1228.

    CAS  PubMed  Google Scholar 

  11. Benkelfat C, Bradwejn J, Meyer E, Ellenbogen M, Milot S, Gjedde A et al. Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers. Am J Psychiatry 1995; 152: 1180–1184.

    CAS  PubMed  Google Scholar 

  12. Gehring WJ, Himle J, Nisenson LG . Action-monitoring dysfunction in obsessive-compulsive disorder. Psychol Sci 2000; 11: 1–6.

    CAS  PubMed  Google Scholar 

  13. Rauch SL, Jenike MA, Alpert NM, Baer L, Breiter HC, Savage CR, et al. Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry 1994; 51: 62–70.

    CAS  PubMed  Google Scholar 

  14. Shin LM, Whalen PJ, Pitman RK, Bush G, Macklin ML, Lasko NB et al. An fMRI study of anterior cingulate function in posttraumatic stress disorder. Biol Psychiatry 2001; 50: 932–942.

    CAS  PubMed  Google Scholar 

  15. Shin LM, McNally RJ, Kosslyn SM, Thompson WL, Rauch SL, Alpert NM et al. Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation. Am J Psychiatry 1999; 156: 575–584.

    CAS  PubMed  Google Scholar 

  16. Stroop JR . Studies of interference in serial verbal reactions. J Exp Psychol 1935; 18: 643–662.

    Google Scholar 

  17. Eriksen BA, Eriksen CW . Effects of noise letters upon the identification of a target letter in a nonsearch task. Perception Psychophysics 1974; 16: 143–149.

    Google Scholar 

  18. Simon JR, Berbaum K . Effect of conflicting cues on information processing: the ‘Stroop effect’ vs the ‘Simon Effect’. Acta Psychol 1990; 73: 159–170.

    CAS  Google Scholar 

  19. Bush G, Vogt BA, Holmes J, Dale AM, Greve D, Jenike MA et al. Dorsal anterior cingulate cortex: a role in reward-based decision making. Proc Natl Acad Sci USA 2002; 99: 523–528.

    CAS  PubMed  Google Scholar 

  20. Barch DM, Braver TS, Akbudak E, Conturo T, Ollinger J, Snyder A . Anterior cingulate cortex and response conflict: effects of response modality and processing domain. Cereb Cortex 2001; 11: 837–848.

    CAS  PubMed  Google Scholar 

  21. Bush G, Luu P, Posner MI . Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 2000; 4: 215–222.

    CAS  PubMed  Google Scholar 

  22. Picard N, Strick PL . Motor areas of the medial wall: a review of their location and functional activation. Cereb Cortex 1996; 6: 342–353.

    CAS  PubMed  Google Scholar 

  23. Drevets WC, Raichle ME . Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive processes: implications for interactions between emotion and cognition. Cognition Emotion 1998; 12: 353–385.

    Google Scholar 

  24. Duncan J, Owen AM . Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends Neurosci 2000; 23: 475–483.

    CAS  PubMed  Google Scholar 

  25. Paus T . Primate anterior cingulate cortex:where motor control, drive and cognition interface. Nat Rev Neurosci 2001; 2: 417–424.

    CAS  PubMed  Google Scholar 

  26. Devinsky O, Morrell MJ, Vogt BA . Contributions of anterior cingulate cortex to behaviour. Brain 1995; 118 (Part 1): 279–306.

    PubMed  Google Scholar 

  27. Mega MS, Cummings JL, Salloway S, Malloy P . The limbic system: an anatomic, phylogenetic, and clinical perspective. J Neuropsychiatry Clin Neurosci 1997; 9: 315–330.

    CAS  PubMed  Google Scholar 

  28. Allman JM, Hakeem A, Erwin JM, Nimchinsky E, Hof P . The anterior cingulate cortex. The evolution of an interface between emotion and cognition. Ann N Y Acad Sci 2001; 935: 107–117.

    CAS  PubMed  Google Scholar 

  29. Vogt BA, Finch DM, Olson CR . Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex 1992; 2: 435–443.

    CAS  PubMed  Google Scholar 

  30. Posner MI, Rothbart MK . Attention self-regulation and consciousness. Philos Trans R Soc London B Biol Sci 1998; 353: 1915–1927.

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Picard N, Strick PL . Imaging the premotor areas. Curr Opin Neurobiol 2001; 11: 663–672.

    CAS  PubMed  Google Scholar 

  32. Shima K, Aya K, Mushiake H, Inase M, Aizawa H, Tanji J . Two movement-related foci in the primate cingulate cortex observed in signal-triggered and self-paced forelimb movements. J Neurophysiol 1991; 65: 188–202.

    CAS  PubMed  Google Scholar 

  33. Gusnard DA, Akbudak E, Shulman GL, Raichle ME . Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci USA 2001; 98: 4259–4264.

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Simpson Jr, JR, Snyder AZ, Gusnard DA, Raichle ME . Emotion-induced changes in human medial prefrontal cortex: I. During cognitive task performance. Proc Natl Acad Sci USA 2001; 98: 683–687.

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Koyama T, Kato K, Tanaka YZ, Mikami A . Anterior cingulate activity during pain-avoidance and reward tasks in monkeys. Neurosci Res 2001; 39: 421–430.

    CAS  PubMed  Google Scholar 

  36. Niki H, Watanabe M . Prefrontal and cingulate unit activity during timing behavior in the monkey. Brain Res 1979; 171: 213–224.

    CAS  PubMed  Google Scholar 

  37. Nishijo H, Yamamoto Y, Ono T, Uwano T, Yamashita J, Yamashima T . Single neuron responses in the monkey anterior cingulate cortex during visual discrimination. Neurosci Lett 1997; 227: 79–82.

    CAS  PubMed  Google Scholar 

  38. Shima K, Tanji J . Role for cingulate motor area cells in voluntary movement selection based on reward. Science 1998; 282: 1335–1338.

    CAS  PubMed  Google Scholar 

  39. Procyk E, Tanaka YL, Joseph JP . Anterior cingulate activity during routine and non-routine sequential behaviors in macaques. Nat Neurosci 2000; 3: 502–508.

    CAS  PubMed  Google Scholar 

  40. Murtha S, Chertkow H, Beauregard M, Dixon R, Evans A . Anticipation causes increased blood flow to the anterior cingulate cortex. Hum Brain Mapping 1996; 4: 103–112.

    CAS  Google Scholar 

  41. Critchley HD, Mathias CJ, Dolan RJ . Neural activity in the human brain relating to uncertainty and arousal during anticipation. Neuron 2001; 29: 537–545.

    CAS  PubMed  Google Scholar 

  42. Shulman GL, Ollinger JM, Linenweber M, Petersen SE, Corbetta M . Multiple neural correlates of detection in the human brain. Proc Natl Acad Sci USA 2001; 98: 313–318.

    CAS  PubMed  Google Scholar 

  43. Clark VP, Fannon S, Lai S, Benson R, Bauer L . Responses to rare visual target and distractor stimuli using event-related fMRI. J Neurophysiol 2000; 83: 3133–3139.

    CAS  PubMed  Google Scholar 

  44. Braver TS, Barch DM, Gray JR, Molfese DL, Snyder A . Anterior cingulate cortex and response conflict: effects of frequency, inhibition and errors. Cereb Cortex 2001; 11: 825–836.

    CAS  PubMed  Google Scholar 

  45. Mesulam MM, Nobre AC, Kim YH, Parrish TB, Gitelman DR . Heterogeneity of cingulate contributions to spatial attention. Neuroimage 2001; 13(6 Part 1): 1065–1072.

    CAS  PubMed  Google Scholar 

  46. Peterson BS, Skudlarski P, Gatenby JC, Zhang H, Anderson AW, Gore JC . An fMRI study of Stroop word–color interference: evidence for cingulate subregions subserving multiple distributed attentional systems. Biol Psychiatry 1999; 45: 1237–1258.

    CAS  PubMed  Google Scholar 

  47. Badgaiyan RD, Posner MI . Mapping the cingulate cortex in response selection and monitoring. Neuroimage 1998; 7: 255–260.

    CAS  PubMed  Google Scholar 

  48. Elliott R, Dolan RJ . Activation of different anterior cingulate foci in association with hypothesis testing and response selection. Neuroimage 1998; 8: 17–29.

    CAS  PubMed  Google Scholar 

  49. Pardo JV, Pardo PJ, Janer KW, Raichle ME . The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. Proc Natl Acad Sci USA 1990; 87: 256–259.

    CAS  PubMed  PubMed Central  Google Scholar 

  50. Paus T, Petrides M, Evans AC, Meyer E . Role of the human anterior cingulate cortex in the control of oculomotor, manual, and speech responses: a positron emission tomography study. J Neurophysiol 1993; 70: 453–469.

    CAS  PubMed  Google Scholar 

  51. Turken AU, Swick D . Response selection in the human anterior cingulate cortex. Nat Neurosci 1999; 2: 920–924.

    CAS  PubMed  Google Scholar 

  52. Knutson B, Westdorp A, Kaiser E, Hommer D . FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage 2000; 12: 20–27.

    CAS  PubMed  Google Scholar 

  53. Kunig G, Leenders KL, Martin-Solch C, Missimer J, Magyar S, Schultz W . Reduced reward processing in the brains of Parkinsonian patients. Neuroreport 2000; 11: 3681–3687.

    CAS  PubMed  Google Scholar 

  54. Gehring WJ, Fencsik DE . Functions of the medial frontal cortex in the processing of conflict and errors. J Neurosci 2001; 21: 9430–9437.

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Kiehl KA, Liddle PF, Hopfinger JB . Error processing and the rostral anterior cingulate: an event-related fMRI study. Psychophysiology 2000; 37: 216–223.

    CAS  PubMed  Google Scholar 

  56. Carter CS, Braver TS, Barch DM, Botvinick MM, Noll D, Cohen JD . Anterior cingulate cortex, error, detection and the online monitoring of performance. Science 1998; 280: 747–749.

    CAS  PubMed  Google Scholar 

  57. Luu P, Flaisch T, Tucker DM . Medial frontal cortex in action monitoring. J Neurosci 2000; 20: 464–469.

    CAS  PubMed  PubMed Central  Google Scholar 

  58. Banich MT, Milham MP, Atchley R, Cohen NJ, Webb A, Wszalek T et al. fMRI studies of Stroop tasks reveal unique roles of anterior and posterior brain systems in attentional selection. J Cogn Neurosci 2000; 12: 988–1000.

    CAS  PubMed  Google Scholar 

  59. MacLeod CM, MacDonald PA . Interdimensional interference in the Stroop effect: uncovering the cognitive and neural anatomy of attention. Trends Cogn Sci 2000; 4: 383–391.

    CAS  PubMed  Google Scholar 

  60. MacDonald 3rd AW, Cohen JD, Stenger VA, Carter CS . Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science 2000; 288: 1835–1838.

    CAS  PubMed  Google Scholar 

  61. Derbyshire SW, Vogt BA, Jones AK . Pain and Stroop interference tasks activate separate processing modules in anterior cingulate cortex. Exp Brain Res 1998; 118: 52–60.

    CAS  PubMed  Google Scholar 

  62. Bush G, Whalen PJ, Rosen BR, Jenike MA, McInerney SC, Rauch SL . The counting Stroop: an interference task specialized for functional neuroimaging—validation study with functional MRI. Hum Brain Mapping 1998; 6: 270–282.

    CAS  Google Scholar 

  63. Taylor SF, Kornblum S, Lauber EJ, Minoshima S, Koeppe RA . Isolation of specific interference processing in the Stroop task: PET activation studies. Neuroimage 1997; 6: 81–92.

    CAS  PubMed  Google Scholar 

  64. Carter CS, Mintun M, Cohen JD . Interference and facilitation effects during selective attention: an H215O PET study of Stroop task performance. Neuroimage 1995; 2: 264–272.

    CAS  PubMed  Google Scholar 

  65. Ruff CC, Woodward TS, Laurens KR, Liddle PF . The role of the anterior cingulate cortex in conflict processing: evidence from reverse stroop interference. Neuroimage 2001; 14: 1150–1158.

    CAS  PubMed  Google Scholar 

  66. Leung HC, Skudlarski P, Gatenby JC, Peterson BS, Gore JC . An event-related functional MRI study of the stroop color word interference task. Cereb Cortex 2000; 10: 552–560.

    CAS  PubMed  Google Scholar 

  67. Botvinick M, Nystrom LE, Fissell K, Carter CS, Cohen JD . Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 1999; 402: 179–181.

    CAS  PubMed  Google Scholar 

  68. Casey BJ, Thomas KM, Welsh TF, Badgaiyan RD, Eccard CH, Jennings JR et al. Dissociation of response conflict, attentional selection, and expectancy with functional magnetic resonance imaging. Proc Natl Acad Sci USA 2000; 97: 8728–8733.

    CAS  PubMed  PubMed Central  Google Scholar 

  69. van Veen V, Cohen JD, Botvinick MM, Stenger VA, Carter CS . Anterior cingulate cortex, conflict monitoring, and levels of processing. Neuroimage 2001; 14: 1302–1308.

    CAS  PubMed  Google Scholar 

  70. Grachev ID, Kumar R, Ramachandran TS, Szeverenyi NM . Cognitive interference is associated with neuronal marker N-acetyl aspartate in the anterior cingulate cortex: an in vivo (1)H-MRS study of the Stroop Color–Word task. Mol Psychiatry 2001; 6: 496, 529–539.

    Google Scholar 

  71. Oldfield RC . The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsycholgia 1971; 9: 97–113.

    CAS  Google Scholar 

  72. Sperling R, Greve D, Dale A, Killiany R, Holmes J, Rosas HD et al. Functional MRI detection of pharmacologically induced memory impairment. Proc Natl Acad Sci USA 2002; 99: 455–460.

    CAS  PubMed  Google Scholar 

  73. Talairach J, Tournoux P . Co-planar Stereotaxic Atlas of the Human Brain. Thieme Medical Publishers: Stuttgart, 1988.

    Google Scholar 

  74. Crosson B, Sadek JR, Bobholz JA, Gokcay D, Mohr CM, Leonard CM et al. Activity in the paracingulate and cingulate sulci during word generation: an fMRI study of functional anatomy. Cereb Cortex 1999; 9: 307–316.

    CAS  PubMed  Google Scholar 

  75. Raichle ME, Fiez JA, Videen TO, MacLeod AM, Pardo JV, Fox PT et al. Practice-related changes in human brain functional anatomy during nonmotor learning. Cereb Cortex 1994; 4: 8–26.

    CAS  PubMed  Google Scholar 

  76. Bench CJ, Frith CD, Grasby PM, Friston KJ, Paulesu E, Frackowiak RS et al. Investigations of the functional anatomy of attention using the Stroop test. Neuropsychologia 1993; 31: 907–922.

    CAS  PubMed  Google Scholar 

  77. Zysset S, Muller K, Lohmann G, von Cramon DY . Color–word matching stroop task: separating interference and response conflict. Neuroimage 2001; 13: 29–36.

    CAS  PubMed  Google Scholar 

  78. Hazeltine E, Poldrack R, Gabrieli JD . Neural activation during response competition. J Cogn Neurosci 2000; 12(Suppl 2): 118–129.

    PubMed  Google Scholar 

  79. Paus T, Koski L, Caramanos Z, Westbury C . Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex: a review of 107 PET activation studies. Neuroreport 1998; 9: R37–R47.

    CAS  PubMed  Google Scholar 

  80. Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME . Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature 1988; 331: 585–589.

    CAS  PubMed  Google Scholar 

  81. Frith CD, Friston K, Liddle PF, Frackowiak RS . Willed action and the prefrontal cortex in man: a study with PET. Proc R Soc London B Biol Sci 1991; 244: 241–246.

    CAS  Google Scholar 

  82. Mesulam MM . Large-scale neurocognitive networks and distributed processing for attention, language and memory. Ann Neurol 1990; 28: 597–613.

    CAS  PubMed  Google Scholar 

  83. Gehring WJ, Willoughby AR . The medial frontal cortex and the rapid processing of monetary gains and losses. Science 2002; 295: 2279–2282.

    CAS  PubMed  Google Scholar 

  84. Gehring WJ, Knight RT . Prefrontal-cingulate interactions in action monitoring. Nat Neurosci 2000; 3: 516–520.

    CAS  PubMed  Google Scholar 

  85. Petit L, Courtney SM, Ungerleider LG, Haxby JV . Sustained activity in the medial wall during working memory delays. J Neurosci 1998; 18: 9429–9437.

    CAS  PubMed  PubMed Central  Google Scholar 

  86. Vogt BA, Nimchinsky EA, Vogt LJ, Hof PR . Human cingulate cortex: surface features, flat maps, and cytoarchitecture. J Comp Neurol 1995; 359: 490–506.

    CAS  PubMed  Google Scholar 

  87. Goldman-Rakic PS . Topography of cognition: parallel distributed networks in primate association cortex. Annu Rev Neurosci 1988; 11: 137–156.

    CAS  PubMed  Google Scholar 

  88. Posner MI, Petersen SE . The attention system of the human brain. Annu Rev Neurosci 1990; 13: 25–42.

    CAS  PubMed  Google Scholar 

  89. Banich MT, Milham MP, Atchley RA, Cohen NJ, Webb A, Wszalek T et al. Prefrontal regions play a predominant role in imposing an attentional ‘set’: evidence from fMRI. Brain Res Cogn Brain Res 2000; 10: 1–9.

    CAS  PubMed  Google Scholar 

  90. Badgaiyan RD . Executive control, willed actions, and nonconscious processing. Hum Brain Mapping 2000; 9: 38–41.

    CAS  Google Scholar 

  91. Koski L, Paus T . Functional connectivity of the anterior cingulate cortex within the human frontal lobe: a brain-mapping meta-analysis. Exp Brain Res 2000; 133: 55–65.

    CAS  PubMed  Google Scholar 

  92. Schubotz RI, von Cramon DY . Functional organization of the lateral premotor cortex: fMRI reveals different regions activated by anticipation of object properties, location and speed. Brain Res Cogn Brain Res 2001; 11: 97–112.

    CAS  PubMed  Google Scholar 

  93. Toni I, Schluter ND, Josephs O, Friston K, Passingham RE . Signal, set- and movement-related activity in the human brain: an event-related fMRI study. Cereb Cortex 1999; 9: 35–49.

    CAS  PubMed  Google Scholar 

  94. Corbetta M, Kincade JM, Ollinger JM, McAvoy MP, Shulman GL . Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Nat Neurosci 2000; 3: 292–297.

    CAS  PubMed  Google Scholar 

  95. Rushworth MF, Paus T, Sipila PK . Attention systems and the organization of the human parietal cortex. J Neurosci 2001; 21: 5262–5271.

    CAS  PubMed  PubMed Central  Google Scholar 

  96. George MS, Ketter TA, Parekh PI, Rosinsky N, Ring H, Casey BJ et al. Regional brain activity when selecting a response despite interference: an H215O PET study of the Stroop and an emotional Stroop. Human Brain Mapping 1994; 1: 194–209.

    CAS  PubMed  Google Scholar 

  97. Paus T, Castro-Alamancos MA, Petrides M . Cortico-cortical connectivity of the human mid-dorsolateral frontal cortex and its modulation by repetitive transcranial magnetic stimulation. Eur J Neurosci 2001; 14: 1405–1411.

    CAS  PubMed  Google Scholar 

  98. Nahas Z, Teneback CC, Kozel A, Speer AM, DeBrux C, Molloy M et al. Brain effects of TMS delivered over prefrontal cortex in depressed adults: role of stimulation frequency and coil-cortex distance. J Neuropsychiatry Clin Neurosci 2001; 13: 459–470.

    CAS  PubMed  Google Scholar 

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Acknowledgements

The authors wish to thank Mary T Foley, Larry White, Larry Wald, Meghan Searl, Kerry Carley-Bush, Jordan Alexander, Taryn Brandon, and our subjects for their patience and assistance. Support for this work was provided by NIMH (Scientist Development Award 01611), NARSAD and the Forrest C Lattner Foundation.

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Bush, G., Shin, L., Holmes, J. et al. The Multi-Source Interference Task: validation study with fMRI in individual subjects. Mol Psychiatry 8, 60–70 (2003). https://doi.org/10.1038/sj.mp.4001217

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