This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Epstein−Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas
Leukemia Open Access 26 June 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Young LS, Rickinson AB . Epstein–Barr virus: 40 years on. Nat Rev Cancer 2004; 10: 757–768.
Boshoff C, Weiss RA . Kaposi's sarcoma-associated herpesvirus. Adv Cancer Res 1998; 75: 57–86.
Masucci MG, Contreras-Salazar B, Ragnar E, Falk K, Minarovits J, Ernberg I et al. 5-Azacytidine up regulates the expression of Epstein–Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael.J Virol 1989; 63: 3135–3141.
Cuomo L, Trivedi P, de Campos-Lima PO, Zhang QJ, Ragnar E, Klein G et al. Selective induction of allostimulatory capacity after 5-azaC treatment of EBV carrying but not EBV negative Burkitt lymphoma cell lines. Mol Immunol 1993; 5: 441–450.
Trivedi P, Takazawa K, Zompetta C, Cuomo L, Anastasiadou E, Carbone A et al. Infection of HHV-8+ primary effusion lymphoma cells with a recombinant Epstein–Barr virus leads to restricted EBV latency, altered phenotype, and increased tumorigenicity without affecting TCL1 expression. Blood 2004; 1: 313–316.
Hertel CB, Zhou XG, Hamilton-Dutoit SJ, Junker S . Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma. Oncogene 2002; 21: 4908–4920.
Li H, Minarovits J . Host cell-dependent expression of latent Epstein–Barr virus genomes: regulation by DNA methylation. Adv Cancer Res 2003; 89: 133–156.
Arguello M, Sgarbanti M, Hernandez E, Mamane Y, Sharma S, Servant M et al. Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines. Oncogene 2003; 20: 964–973.
Kis LL, Nishikawa J, Takahara M, Nagy N, Matskova L, Takada K et al. In vitro EBV-infected subline of KMH2, derived from Hodgkin lymphoma, expresses only EBNA-1, while CD40 ligand and IL-4 induce LMP-1 but not EBNA-2. Int J Cancer 2005; 113: 937–945.
Jones KD, Aoki Y, Chang Y, Moore PS, Yarchoan R, Tosato G . Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells. Blood 1999; 94: 2871–2879.
Chan AT, Tao Q, Robertson KD, Flinn IW, Mann RB, Klencke B et al. Azacytidine induces demethylation of the Epstein–Barr virus genome in tumors. J Clin Oncol 2004; 22: 1373–1381.
Acknowledgements
This work was supported by grants from the MIUR, Ministero della Sanità, Progetto AIDS, Associazione Italiana di ricerca sul Cancro (AIRC) and Istituto-Cenci-Bolognetti foundation. We gratefully acknowledge Drs Kenzo Takada and Antonino Carbone for providing the recombinant EBV strain and PEL cell lines, respectively. Miss Claudia Zompetta and Mr Sandro Valia provided skillful technical assistance.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Anastasiadou, E., Boccellato, F., Cirone, M. et al. Epigenetic mechanisms do not control viral latency III in primary effusion lymphoma cells infected with a recombinant Epstein–Barr virus. Leukemia 19, 1854–1856 (2005). https://doi.org/10.1038/sj.leu.2403895
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2403895