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BCL10 mutations are irrelevant to its aberrant nuclear localization in nasal NK/T-cell lymphoma

Leukemia volume 17, pages 2240–2242 (2003)Cite this article

TO THE EDITOR

The BCL10 gene, originally identified through its recurrent involvement in t(1;14)(p22;q32) of the mucosa-associated lymphoid tissue (MALT) lymphoma, encodes a cytosolic protein composed of 233 amino-acid residues with proapoptotic and proinflammatory activities, whereas mutated BCL10, causing C-terminal truncation, can operate as an oncogene.1 BCL10 is widely expressed in normal lymphoid tissues, with the expression level depending on the developmental stage of lymphocytes.2 Many B-cell lymphomas, including MALT lymphoma, also express BCL10.2 In contrast to the normal B cells that express BCL10 in the cytoplasm, MALT lymphoma cells with t(1;14)(p22;q32) or t(11;18)(q21;q21) translocation express the protein predominantly in the nucleus.2,3,4 Recently, we reported that BCL10 is expressed in the cytoplasm of normal NK cells, and demonstrated its aberrant nuclear localization in the tumor cells of nasal NK/T-cell lymphomas (NL).5 Many NL tumors have the same nuclear staining of BCL10 as the MALT lymphomas, but the chromosomal translocations t(1;14)(p22;q32) or t(11;18)(q21;q21) that are the hallmark of MALT lymphoma2,3,4 are not present in NL,6 implicating an alternative mechanism leading to aberrant BCL10 nuclear localization during tumorigenesis of NL.5 In this study, we examined BCL10 gene mutations in normal NK cells and NL, and investigated whether these mutations were associated with the aberrant BCL10 localization in the nucleus in NL.

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Acknowledgements

This study was supported by a grant from the Research Grants Council of Hong Kong Special Administrative Region, PR China (HKU 7348/02M to GS).

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Authors and Affiliations

  1. Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong

    L Shen, A C T Liang, L Lu, Y W Chen, K Y Wong, K W Chan, S L Beh & G Srivastava

  2. Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong

    W Y Au, Y L Kwong & R H S Liang

  3. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong

    J C O Tang

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  1. L Shen
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Shen, L., Liang, A., Au, W. et al. BCL10 mutations are irrelevant to its aberrant nuclear localization in nasal NK/T-cell lymphoma. Leukemia 17, 2240–2242 (2003). https://doi.org/10.1038/sj.leu.2403128

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