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Cost–effectiveness of repeated aphereses in poor mobilizers undergoing high-dose chemotherapy and autologous hematopoietic cell transplantation

Leukemia volume 17, pages 811–813 (2003)Cite this article

TO THE EDITOR

We retrospectively analyzed a cohort of 435 patients who – from 1992 to 1998 – received high-dose chemotherapy and autologous blood cell transplantation for a variety of nonleukemic malignancies at a single institution. Autologous cells and progenitors were mobilized in the blood, with daily administration of rhG-CSF (Filgrastim, Amgen, Thousand Oaks, CA, USA): 600 μg per day SQ, or after administration of various chemotherapy regimens, followed by the daily administration of rhG-CSF, 300 μg per day SQ, starting on day 6, as per institutional protocols. Patients were collected by apheresis: two blood masses were treated, using a Cobe Spectra (Gambro BCT) automated processor; autologous grafts were characterized for their content in CD34+ cells, using murine monoclonal antibodies directed to the CD34 and CD45 antigens, and flow cytometry, according to institutional protocols.

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Acknowledgements

This work was supported in part by Institut Paoli-Calmettes. The authors thank Mr Christian Cailliot at Amgen France for his support during the conduct of this study.

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Authors and Affiliations

  1. Institut Paoli-Calmettes, Centre Régional de Lutte, Contre le Cancer Provence-Alpes-Côte d'Azur, Marseille, France

    C Chabannon, F Viret, C Faucher, P Viens, N Vey, A-C Braud, G Novakovitch, P Ladaique, A-M Stoppa, J Camerlo, D Genre, D Maraninchi & D Blaise

  2. Inserm U379, Marseille, France

    A-G Le Corroller, C Eillen & J-P Moatti

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  1. C Chabannon
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  2. A-G Le Corroller
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Chabannon, C., Le Corroller, AG., Viret, F. et al. Cost–effectiveness of repeated aphereses in poor mobilizers undergoing high-dose chemotherapy and autologous hematopoietic cell transplantation. Leukemia 17, 811–813 (2003). https://doi.org/10.1038/sj.leu.2402867

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  • DOI: https://doi.org/10.1038/sj.leu.2402867

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