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Evaluation of minimal residual disease by interphase FISH in multiple myeloma: does complete remission exist?

Leukemia volume 13, pages 641–644 (1999)Cite this article

Abstract

As in other hematological malignancies, the achievement of a complete remission (CR) is important in multiple myeloma but is still based on common cytological and electrophoretic criteria. In this report, we studied 14 patients who achieved an apparent CR following high-dose therapy using fluorescence in situ hybridization (FISH) analysis. Although the results were difficult to interpret in two patients, 12 of 14 patients had unequivocal persistence of abnormal plasma cells in their bone marrow. Our results suggest that only a few patients, if any, are in true CR following one course of high-dose therapy and are in favor of post-transplantation treatments.

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Authors and Affiliations

  1. Laboratoire d’Hématologie, Angers, Hôpital Huriez, Lille, France

    F Genevieve & M Zandecki

  2. Laboratoire de Génétique, Lille, Hôpital Huriez, Lille, France

    J-L Laï

  3. Laboratoire de Biochimie, Lille, Hôpital Huriez, Lille, France

    B Hennache & J-L Faucompre

  4. Service des Maladies du Sang, Hôpital Huriez, Lille, France

    L Stalnikiewicz, F Bauters & T Facon

Authors
  1. F Genevieve
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  2. M Zandecki
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  3. J-L Laï
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  4. B Hennache
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  5. J-L Faucompre
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  6. L Stalnikiewicz
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  7. F Bauters
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  8. T Facon
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Cite this article

Genevieve, F., Zandecki, M., Laï, JL. et al. Evaluation of minimal residual disease by interphase FISH in multiple myeloma: does complete remission exist?. Leukemia 13, 641–644 (1999). https://doi.org/10.1038/sj.leu.2401348

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  • DOI: https://doi.org/10.1038/sj.leu.2401348

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