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Prognostic Studies

Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup

Leukemia volume 13, pages 19–21 (1999)Cite this article

Abstract

The long-term outcome of children with TEL-AML1-positive acute lymphoblastic leukemia (ALL) is uncertain. Although studies of newly diagnosed cases have indicated that the TEL-AML1 fusion confers a favorable prognosis, analyses of relapsed cases have suggested that this may not be true. Because of treatment implications for this subgroup of patients, we have now analyzed 49 cases of relapsed ALL for the presence of TEL-AML1. Only 10% of these cases expressed the fusion, compared to 20–25% of newly diagnosed ALL cases. Additional follow-up of the cohort of 48 newly diagnosed patients with the TEL-AML1 fusion previously reported showed that the 10-year cumulative risk of relapse was 9 ± 5% (s.e.). Together, these results suggest an excellent outcome for TEL-AML1-positive ALL.

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Authors and Affiliations

  1. Department of Hematology/Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee, USA

    JE Rubnitz, D Wichlan, C Ryan, JT Sandlund, RC Ribeiro, GK Rivera & C-H Pui

  2. Department of Pathology and Laboratory Medicine, St Jude Children’s Research Hospital, Memphis, Tennessee, USA

    FG Behm, C-H Pui & JR Downing

  3. Department of Tumor Cell Biology, St Jude Children’s Research Hospital, Memphis, Tennessee, USA

    JR Downing

  4. Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, Tennessee, USA

    ML Hancock

  5. Department of Pharmaceutical Sciences, St Jude Children’s Research Hospital, Memphis, Tennessee, USA

    MV Relling & WE Evans

  6. Department of Pediatrics, University of Tennessee College of Medicine, Memphis, Tennessee, USA

    JE Rubnitz, JT Sandlund, RC Ribeiro, GK Rivera & C-H Pui

  7. Department of Pathology, University of Tennessee College of Medicine, Memphis, Tennessee, USA

    FG Behm

  8. Department of Pharmacy, University of Tennessee College of Medicine, Memphis, Tennessee, USA

    MV Relling & WE Evans

Authors
  1. JE Rubnitz
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  2. FG Behm
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  3. D Wichlan
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  4. C Ryan
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  5. JT Sandlund
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  6. RC Ribeiro
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  7. GK Rivera
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  8. ML Hancock
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  9. MV Relling
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  10. WE Evans
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  11. C-H Pui
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  12. JR Downing
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Rubnitz, J., Behm, F., Wichlan, D. et al. Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup. Leukemia 13, 19–21 (1999). https://doi.org/10.1038/sj.leu.2401257

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  • DOI: https://doi.org/10.1038/sj.leu.2401257

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