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Gender, obesity, hepatic nuclear factor-1α G319S and the age-of-onset of type 2 diabetes in Canadian Oji-Cree

International Journal of Obesity volume 24, pages 1062–1064 (2000)Cite this article

Abstract

Among the Oji-Cree of northern Ontario, women have both a higher prevalence and an earlier onset of type 2 diabetes compared to men. We studied the relationship between HNF1A S319 and both the presence of and the age-of-onset of type 2 diabetes in women and men separately. We found that: 1) in women, there was a significant difference in the mean age-of-onset of type 2 diabetes according to HNF1A genotype; and 2) in men, there was no difference in the mean age-of-onset of type 2 diabetes according to HNF1A genotype. The findings indicate that HNF1A S319 is associated with increased susceptibility to type 2 diabetes in both men and women, but with earlier age-of-onset in women only. One factor that might account for the gender difference in the onset of HNF1A S319-associated type 2 diabetes is the greater prevalence and severity, and earlier onset of, obesity among female Oji-Cree.

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Acknowledgements

We would like to acknowledge the chief and council of the community of Sandy Lake; the Sandy Lake community surveyors; the Sandy Lake nurses; the staff of the University of Toronto Sioux Lookout programme; and the Department of Clinical Epidemiology of the Samuel Lunenfeld Research Institute. This work was supported by grants from the National Institutes of Health (DK44597-01), the Ontario Ministry of Health (no. 04307), the Medical Research Council of Canada (MT13430), the Canadian Diabetes Association (in honour of Rheta Maude Gilbert) and the Blackburn Group. Dr Hegele is a Career Investigator of the Heart and Stroke Foundation of Ontario. Dr Harris is a Career Investigator of the Ontario Ministry of Health. Mr Hanley is supported by Health Canada through a National Health Research and Development Program Research Training Award.

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Authors and Affiliations

  1. John P Robarts Research Institute, London, Ontario, Canada

    RA Hegele, H Cao & CM Anderson

  2. Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada

    SB Harris

  3. Samuel Lunenfeld Research Institute and Department of Medicine, Mount Sinai Hospital, University of Toronto, Ontario, Canada

    B Zinman & AJG Hanley

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  1. RA Hegele
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  2. H Cao
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  3. SB Harris
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  4. B Zinman
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  5. AJG Hanley
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  6. CM Anderson
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Correspondence to RA Hegele.

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Hegele, R., Cao, H., Harris, S. et al. Gender, obesity, hepatic nuclear factor-1α G319S and the age-of-onset of type 2 diabetes in Canadian Oji-Cree. Int J Obes 24, 1062–1064 (2000). https://doi.org/10.1038/sj.ijo.0801258

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