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Lombardi T, Samson J et al. J Oral Pathol Med 2004; 33: 115–120

Numerous substances (some resorbable in 4-6 months, some biodegradable and inducing new collagen, and others which are permanent implants) have been prepared for removing or reducing facial skin wrinkles. This paper lists 11 cases of granulomata following such injections in women of mean age 55 yrs.

Nodules presented in cheek, glabella, upper lip, lower lip, nasolabial groove and lower eyelid in different patients, varying in clinical appearance from salivary cyst to basal cell carcinoma. Biopsy revealed 2 main types of lesion: one was described as a classic foreign body granuloma, and the other as a cystic and macrophage type.

In 5 cases, pain or discomfort was a presenting symptom. In 8 cases, the presentation was known to have occurred between 6 months and 6 yrs after the injection. Legal action had been taken against the responsible practitioner by at least one patient. The authors comment on the bizarre histological appearance of some lesions.