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SULFUR METABOLISM

GSH hoards all the cysteine—what a slimy thing to do

Nature Metabolism volume 3, pages 297–298 (2021)Cite this article

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Nutrient availability dictates cell differentiation and transition through the Dictyostelium discoideum life cycle. Kelly et al. reveal that the increase in reactive oxygen species associated with nutrient limitation coincides with a sequestration of available cysteine in glutathione, thus limiting sulfur-dependent mitochondrial respiration and promoting aggregation into the differentiated spore form.

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Fig. 1: Rewiring of sulfur metabolism under nutrient limitation inhibits mitochondrial function and promotes D. discoideum aggregation.

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Authors and Affiliations

  1. Department of Cancer Physiology, Moffitt Cancer Center, Tampa, FL, USA

    Nathan P. Ward & Gina M. DeNicola

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  1. Nathan P. Ward
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  2. Gina M. DeNicola
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Correspondence to Nathan P. Ward or Gina M. DeNicola.

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The authors declare no competing interests.

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Ward, N.P., DeNicola, G.M. GSH hoards all the cysteine—what a slimy thing to do. Nat Metab 3, 297–298 (2021). https://doi.org/10.1038/s42255-021-00365-z

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