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PROTEOLYSIS

How to build a proteasome

The biogenesis of eukaryotic 20S proteasomes requires the accurate assembly of 14 closely related protein subunits and occurs in a complex series of chaperone-dependent steps. Important insights into this pathway are now provided by the high-resolution cryo-EM structures of two 20S proteasome assembly intermediates.

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Fig. 1: Abbreviated overview of the 20S proteasome assembly pathway.
Fig. 2: Schematic representation of the arrangement of proteasome subunits and chaperones in the 13S and pre-15S proteasome assembly intermediates.

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Acknowledgements

We thank the University of Glasgow for their support.

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Correspondence to Paula C. A. da Fonseca.

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Morris, E.P., da Fonseca, P.C.A. How to build a proteasome. Nat Struct Mol Biol 28, 409–410 (2021). https://doi.org/10.1038/s41594-021-00592-8

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