Abstract
Members of the Oxa1 superfamily perform membrane protein insertion in bacteria, the eukaryotic endoplasmic reticulum (ER), and endosymbiotic organelles. Here, we review recent structures of the three ER-resident insertases and discuss the extent to which structure and function are conserved with their bacterial counterpart YidC.
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Acknowledgements
This work was supported by an EMBO Long Term Fellowship (ALTF 1230-2013) to M.A.M. and by the DFG through the Leibniz Programme (SI 586/6-1) and TRR83 (TP22) to I.S.
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McDowell, M.A., Heimes, M. & Sinning, I. Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily. Nat Struct Mol Biol 28, 234–239 (2021). https://doi.org/10.1038/s41594-021-00567-9
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DOI: https://doi.org/10.1038/s41594-021-00567-9
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