Antisense oligonucleotides that target lamin A/C pre-mRNA decrease both progerin transcript levels and progerin protein levels and extend lifespan in an animal model of Hutchinson–Gilford progeria syndrome.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Eriksson, M. et al. Nature 423, 293–298 (2003).
De Sandre-Giovannoli, A. et al. Science 300, 2055 (2003).
Gordon, L. B., Rothman, F. G., López-Otín, C. & Misteli, T. Cell 156, 400–407 (2014).
Erdos, M.R. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01274-0 (2021).
Puttaraju, M. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01262-4 (2021).
Bennett, C. F. Annu. Rev. Med. 70, 307–321 (2019).
Osorio, F. G. et al. Sci. Transl. Med. 3, 106ra107 (2011).
Lee, J. M. et al. J. Clin. Invest. 126, 1592–1602 (2016).
Aguado, J. et al. Nat. Commun. 10, 4990 (2019).
Rosengardten, Y., McKenna, T., Grochová, D. & Eriksson, M. Aging Cell 10, 1011–1020 (2011).
Koblan, L. W. et al. Nature 589, 608–614 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Revêchon, G., Whisenant, D. & Eriksson, M. Splice-inhibition therapy targets progeria. Nat Med 27, 377–379 (2021). https://doi.org/10.1038/s41591-021-01267-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-021-01267-z
