The N6-methyladenosine (m6A) RNA-modification pathway affects numerous aspects of immune responses. A new study now demonstrates that m6A modification of transcripts encoding lysosomal proteases limits the efficiency of tumor-antigen cross-presentation.
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References
Han, D. et al. Nature 566, 270–274 (2019).
Meyer, K. D. & Jaffrey, S. R. Annu. Rev. Cell Dev. Biol. 33, 319–342 (2017).
Li, H.-B. et al. Nature 548, 338–342 (2017).
Winkler, R. et al. Nat. Immunol. 20, 173–182 (2019).
Shi, H. et al. Nature 563, 249–253 (2018).
Theisen, D. J. et al. Science 362, 694–699 (2018).
Theisen, D. J. et al. Cancer Immunol. Res. 7, 29–39 (2019).
Alloatti, A. et al. J. Exp. Med. 214, 2231–2241 (2017).
Joffre, O. P., Segura, E., Savina, A. & Amigorena, S. Nat. Rev. Immunol. 12, 557–569 (2012).
Gros, M. & Amigorena, S. Front. Immunol. 10, 41 (2019).
Samie, M. & Cresswell, P. Nat. Immunol. 16, 729–736 (2015).
Kreiter, S. et al. Nature 520, 692–696 (2015).
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Burbage, M., Gros, M. & Amigorena, S. Translate less, prime better, to improve anti-tumor responses. Nat Immunol 20, 518–520 (2019). https://doi.org/10.1038/s41590-019-0371-8
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DOI: https://doi.org/10.1038/s41590-019-0371-8
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