A new study addresses whether transcription of enhancers and the resulting enhancer RNAs (eRNAs) play a role in mediating long-range interactions between enhancers and promoters. Studying the immunoglobulin heavy chain (Igh) locus, the authors find that transcription of the enhancers per se is required to establish but not maintain these interactions, and this mechanism may apply to a subset of other enhancer–promoter interactions.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Rho enhancers play unexpectedly minor roles in Rhodopsin transcription and rod cell integrity
Scientific Reports Open Access 09 August 2023
-
Regulation of chromatin organization during animal regeneration
Cell Regeneration Open Access 01 June 2023
-
3D chromatin architecture and transcription regulation in cancer
Journal of Hematology & Oncology Open Access 04 May 2022
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
03 March 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00815-0
References
Furlong, E. E. M. & Levine, M. Science 361, 1341–1345 (2018).
Grosveld, F., van Assendelft, G. B., Greaves, D. R. & Kollias, G. Cell 51, 975–985 (1987).
Higgs, D. R. et al. Genes Dev. 4, 1588–1601 (1990).
Fudenberg, G. et al. Cell Rep. 15, 2038–2049 (2016).
Rao, S. S. P. et al. Cell 171, 305–320.e24 (2017).
Heinz, S., Romanoski, C. E., Benner, C. & Glass, C. K. Nat. Rev. Mol. Cell Biol. 16, 144–154 (2015).
Tippens, N. D., Vihervaara, A. & Lis, J. T. Genes Dev. 32, 1–3 (2018).
Zhang, H. et al. Nature 576, 158–162 (2019).
Fitz, J. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0605-6 (2020).
Gu, B. et al. Science 359, 1050–1055 (2018).
Germier, T. et al. Biophys. J. 113, 1383–1394 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Higgs, D.R. Enhancer–promoter interactions and transcription. Nat Genet 52, 470–471 (2020). https://doi.org/10.1038/s41588-020-0620-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-020-0620-7
This article is cited by
-
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
Nature Structural & Molecular Biology (2024)
-
Regulation of chromatin organization during animal regeneration
Cell Regeneration (2023)
-
Rho enhancers play unexpectedly minor roles in Rhodopsin transcription and rod cell integrity
Scientific Reports (2023)
-
Photoselective sequencing: microscopically guided genomic measurements with subcellular resolution
Nature Methods (2023)
-
3D chromatin architecture and transcription regulation in cancer
Journal of Hematology & Oncology (2022)