Addendum to: Nature https://doi.org/10.1038/416560a Published online 4 April 2002

Nature is publishing an editorial expression of concern on the article “p63 and p73 are required for p53-dependent apoptosis in response to DNA damage” from Flores et al. to alert the readership that image integrity issues have been raised with some of the data.

The first and corresponding author have been able to confirm the integrity of the data in Figures 2b, 3b and 4a, with the original source data, and have provided contemporaneous replicates for some experiments. Given the age of the paper there is insufficient information to conclusively assess potential image integrity issues in Figure 4b. However, analysis by the authors and the journal has confirmed that Supplementary Figure S4b contains duplicated images, which the authors believe was due to an error in the assembly of this supplementary figure.

Readers are urged to take this information into consideration when interpreting the data presented in this article. All the authors agree with the Editorial Expression of Concern.