Nelson and colleagues compare whole body, skeletal muscle and white adipose tissue insulin resistance in inbred mouse strains fed a chow or a Western diet. They report large strain-related differences in diet-induced effects on weight gain and insulin action, and demonstrate that tissue-specific insulin sensitivity can be disentangled from systemic insulin resistance.
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Mejhert, N., Rydén, M. Understanding the complexity of insulin resistance. Nat Rev Endocrinol 18, 269–270 (2022). https://doi.org/10.1038/s41574-022-00648-9
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DOI: https://doi.org/10.1038/s41574-022-00648-9
