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DEVELOPMENT

Mammary lineage restriction in development

The establishment of the two distinct lineages that form the branched epithelial ductal tree of the mammary gland is a complex and essential developmental process. Two independent studies now describe the switch from multipotency to unipotency as an embryonic process and outline mechanisms of early lineage restriction.

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Fig. 1: Schematic representation of embryonic bifurcation of the mammary lineage and reprogramming of mammary epithelial cells after lineage restriction.

References

  1. Van Keymeulen, A. et al. Nature 479, 189–193 (2011).

    Article  PubMed  CAS  Google Scholar 

  2. Visvader, J. E. & Clevers, H. Nat. Cell Biol. 18, 349–355 (2016).

    Article  PubMed  CAS  Google Scholar 

  3. Watson, C. J. & Khaled, W. T. Development 135, 995–1003 (2008).

    Article  PubMed  CAS  Google Scholar 

  4. Lilja, A. M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0108-1 (2018).

  5. Wuidart, A. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0095-2 (2018).

  6. Buono, K. D. et al. Dev. Biol. 293, 565–580 (2006).

    Article  PubMed  CAS  Google Scholar 

  7. Bouras, T. et al. Cell Stem Cell 3, 429–441 (2008).

    Article  PubMed  CAS  Google Scholar 

  8. Howard, B. A. & Lu, P. Semin. Cell Dev. Biol. 25–26, 43–51 (2014).

    Article  PubMed  CAS  Google Scholar 

  9. Lindström, L. S. et al. J. Clin. Oncol. 30, 2601–2608 (2012).

    Article  PubMed  Google Scholar 

  10. Zvelebil, M. et al. Breast Cancer Res. 15, R25 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Van Keymeulen, A. et al. Nature 525, 119–123 (2015).

    Article  PubMed  CAS  Google Scholar 

  12. Koren, S. et al. Nature 525, 114–118 (2015).

    Article  PubMed  CAS  Google Scholar 

  13. Oliemuller, E. et al. J. Pathol. 243, 193–207 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  14. Malta, T. M. et al. Cell 173, 338–354 (2018).

    Article  PubMed  CAS  Google Scholar 

  15. Lin-Shiao, E. et al. Genes Dev. 32, 181–193 (2018).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

Download references

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Correspondence to Beatrice A. Howard.

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Bland, P., Howard, B.A. Mammary lineage restriction in development. Nat Cell Biol 20, 637–639 (2018). https://doi.org/10.1038/s41556-018-0111-6

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