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NON-CODING RNA

A lncRNA GUARDINg genome integrity

Nature Cell Biology volume 20, pages 371–372 (2018)Cite this article

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A coordinated DNA damage response mediated by p53 to repair DNA lesions or to promote apoptosis is essential for maintenance of genome stability. A study now unveils the long non-coding RNA GUARDIN as a component of this pathway, which protects genome integrity in a pleiotropic fashion.

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Fig. 1: GUARDIN preserves genome integrity through multiple mechanisms.

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Authors and Affiliations

  1. Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

    Elena Grossi & Maite Huarte

  2. Health Research Institute of Navarra (IdiSNA), Pamplona, Spain

    Elena Grossi & Maite Huarte

Authors
  1. Elena Grossi
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  2. Maite Huarte
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Correspondence to Maite Huarte.

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The authors declare no competing interests.

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Grossi, E., Huarte, M. A lncRNA GUARDINg genome integrity. Nat Cell Biol 20, 371–372 (2018). https://doi.org/10.1038/s41556-018-0075-6

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