Nanoscale metal–organic frameworks carrying an immunotherapy payload and administered into tumours alongside a low dose of radiotherapy enhance local and systemic antitumour immunity in mouse models of breast cancer and colorectal cancer.
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References
Stewart, B. W. & Wild, C. P. (eds) World Cancer Report 2014 1–2 (World Health Organization, Lyon, France, 2014).
Atun, R. et al. Lancet Oncol. 16, 1153–1186 (2015).
Mole, R. H. Br. J. Radiol. 26, 234–241 (1953).
Andrews, J. R. The Radiobiology of Human Cancer Radiotherapy (University Park Press, Baltimore, MD, USA, 1978).
Ngwa, W. et al. Nat. Rev. Cancer 18, 313–322 (2018).
Tang, C. et al. Cancer Immunol. Res. 2, 831–838 (2014).
Formenti, S. C. & Demaria, S. J. Natl Cancer Inst. 105, 256–265 (2013).
Lu, K. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0203-4 (2018).
Mellor, A. L. & Munn, D. H. Nat. Rev. Immunol. 4, 762–774 (2004).
Toy, R. & Roy, K. Bioeng. Transl. Med. 1, 47–62 (2016).
Ngwa, W. et al. Nanomedicine 9, 1063–1082 (2014).
Chaffer, C. L. & Weinberg, R. A. Science 331, 1559–1564 (2011).
Bernstein, M. B., Krishnan, S., Hodge, J. W. & Chang, J. Y. Nat. Rev. Clin. Oncol. 13, 516–524 (2016).
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Ngwa, W. Systemic immune effects boost radiotherapy. Nat Biomed Eng 2, 562–563 (2018). https://doi.org/10.1038/s41551-018-0264-4
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DOI: https://doi.org/10.1038/s41551-018-0264-4