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Immunotherapy

The efficacy and safety of CAR-T cell therapy in patients with refractory ALL and concomitant HBV infection

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Fig. 1: CAR-T cells from HBV patients displayed potent antileukemic activity.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81870121); Guangdong Basic and Applied Basic Research Foundation (No. 2019A1515010094); and the Project of Administration of Traditional Chinese Medicine of Guangdong Province (20191008).

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J Weng, X Du, P Li, and P Lai conceived and designed the study. P Lai, X Chen, L Qin, Z Jiang, C Luo, X Huang, S Wu, W Ling, Y Wang, J Wang, C Deng, and L Huang performed the main experiments and analyses. L Zeng, Z Lu, L Zhong, P Liao, M Li, D Chen, P Wu, and S Geng assisted in diagnostic interpretation of patient samples, and clinical monitor of patients’ condition. P Lai, J Weng, X Du, and P Li wrote the paper. Z Tang, and D Pei provide conceptual advice and revised the paper. All authors read and approved the final paper.

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Correspondence to Xin Du, Peng Li or Jianyu Weng.

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Lai, P., Chen, X., Qin, L. et al. The efficacy and safety of CAR-T cell therapy in patients with refractory ALL and concomitant HBV infection. Leukemia 34, 2790–2793 (2020). https://doi.org/10.1038/s41375-020-0952-4

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