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Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome

Prostate Cancer and Prostatic Diseases volume 13, pages 338–342 (2010)Cite this article

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Abstract

The purpose of this study was to assess the diagnostic value and potentially protective capacity of heat-shock protein 70 (HSP70) in chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). In this study, seminal plasma levels of cytokines (tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β)) and HSP70 were evaluated by enzyme-linked immunosorbent assay in 80 men: 15 healthy controls, 16 men with chronic bacterial prostatitis, 23 men with CP/CPPS IIIA and 26 with CP/CPPS IIIB. The HSP70 levels in chronic bacterial prostatitis and CP/CPPS patients were correlated with chronic prostatitis symptom index (CPSI). Significantly increased levels of cytokines (TNF-α and IL-1β) and HSP70 were observed in seminal plasmas from patients with chronic bacterial prostatitis compared with CP/CPPS patients and controls. However, only IL-1β was significantly elevated compared with CP/CPPS IIIB and controls in patients with CP/CPPS IIIA. HSP70 levels in CP/CPPS patients were significantly lower than that in controls. HSP70 concentration in seminal plasma was negatively correlated with CPSI in chronic bacterial prostatitis. The results indicated that HSP70 and IL-1β appear to be the most reliable and predictive surrogate markers to diagnose chronic bacterial prostatitis and CP/CPPS, respectively. HSP70 has an important protective role in the regulation of cell functions in chronic bacterial prostatitis. CP/CPPS would probably be detrimental to the ability of T cells and consequently suppress the expression of HSP70.

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Acknowledgements

We thank Doctor Jian Bai of the Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology for his assistance in writing and preparing this paper.

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Authors and Affiliations

  1. Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China

    H Guo, Y-M Xu, Q Fu, Y-L Sa, X-Y Hu & L-J Song

  2. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China

    Z-Q Ye

  3. Department of Urology, Hubei Provincial Corps Hospital, Chinese People's Armed Police Forces, Hubei, China

    J-H Yu

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Correspondence to Y-M Xu.

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Guo, H., Xu, YM., Ye, ZQ. et al. Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome. Prostate Cancer Prostatic Dis 13, 338–342 (2010). https://doi.org/10.1038/pcan.2010.22

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