Abstract
The Mitf gene has a key role in melanocytes and melanoma by regulating cell cycle progression, survival and differentiation. Two papers in this issue of Oncogene (Cheli et al., 2011; Strub et al., 2011) reveal that low-Mitf cells can initiate tumors with high efficiency, and that Mitf blocks senescence by regulating genes implicated in S-phase progression and mitosis.
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Goding, C. A picture of Mitf in melanoma immortality. Oncogene 30, 2304–2306 (2011). https://doi.org/10.1038/onc.2010.641
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DOI: https://doi.org/10.1038/onc.2010.641
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