Abstract
One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/PUMA (potent inducers of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis. These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis.
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Acknowledgements
We appreciate ongoing discussions with Drs Bennett Van Houten, Douglas Green, Charleen Chu, and Lin Zhang about the issues of apoptosis and autophagy.
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Tang, D., Lotze, M., Kang, R. et al. Apoptosis promotes early tumorigenesis. Oncogene 30, 1851–1854 (2011). https://doi.org/10.1038/onc.2010.573
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DOI: https://doi.org/10.1038/onc.2010.573
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