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The SWI/SNF complex and cancer

Oncogene volume 28, pages 1653–1668 (2009)Cite this article

Abstract

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

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  1. Department of Internal Medicine, University of Michigan College of Medicine, Ann Arbor, MI, USA

    D Reisman & S Glaros

  2. Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL, USA

    E A Thompson

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Reisman, D., Glaros, S. & Thompson, E. The SWI/SNF complex and cancer. Oncogene 28, 1653–1668 (2009). https://doi.org/10.1038/onc.2009.4

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