Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Blocking HIV-1 virus assembly

Nature Structural & Molecular Biology volume 12, pages 638–639 (2005)Cite this article

Two recent papers identify the first peptide inhibitor that binds to the structural protein of HIV-1, thereby blocking assembly of both immature and mature virus-like particles in vitro. These studies open the door to a strategy for the development of new therapies against the virus.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic representation of immature and mature HIV-1 particles.

References

  1. Ganser, B.K., Li, S., Klishko, V.Y., Finch, J.T. & Sundquist, W.I. Science 283, 80–83 (1999).

    Article  CAS  Google Scholar 

  2. Gross, I. et al. EMBO J. 19, 103–113 (2000).

    Article  CAS  Google Scholar 

  3. Li, S., Hill, C.P., Sundquist, W.I. & Finch, J.T. Nature 407, 409–413 (2000).

    Article  CAS  Google Scholar 

  4. Lanman, J. et al. J. Mol. Biol. 325, 759–772 (2003).

    Article  CAS  Google Scholar 

  5. Sticht, J. et al. Nat. Struct. Mol. Biol. 12, 671–677 (2005).

    Article  CAS  Google Scholar 

  6. Briggs, J.A.G., Wilk, T., Welker, R., Kräusslich, H.-G. & Fuller, S.D. EMBO J. 22, 1707–1715 (2003).

    Article  CAS  Google Scholar 

  7. Cairns, T.M. & Craven, R.C. J. Virol. 75, 242–250 (2001).

    Article  CAS  Google Scholar 

  8. Ivanov, D., Stone, J.R., Maki, J.L., Collins, T. & Wagner, G. Mol. Cell 17, 137–143 (2005).

    Article  CAS  Google Scholar 

  9. Ternois, F., Sticht, J., Duquerroy, S., Kräusslich, H.-G. & Rey, F.A. Nat. Struct. Mol. Biol. 12, 678–682 (2005).

    Article  CAS  Google Scholar 

  10. Li, F. et al. Proc. Natl. Acad. Sci. USA 100, 13555–13560 (2003).

    Article  CAS  Google Scholar 

  11. Zhou, J. et al. J. Virol. 78, 922–929 (2004).

    Article  CAS  Google Scholar 

  12. Tang, C. et al. J. Mol. Biol. 327, 1013–1020 (2003).

    Article  CAS  Google Scholar 

  13. Briggs, J.A.G. et al. Nat. Struct. Mol. Biol. 11, 672–675 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Molecular Biology and Genetics, Cornell University, Ithaca, 14853, New York, USA

    Volker M Vogt

Authors
  1. Volker M Vogt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vogt, V. Blocking HIV-1 virus assembly. Nat Struct Mol Biol 12, 638–639 (2005). https://doi.org/10.1038/nsmb0805-638

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0805-638

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing