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Insights into DNA deaminases

The structures of APOBEC2 and TadA, members of a superfamily of Zn-dependent deaminases, reveal unexpected features and provide insight into the ability of some family members to act on DNA.

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Figure 1: APOBEC2 has a subunit organization that differs from those of previously characterized zinc-dependent deaminases.
Figure 2: Comparison of the secondary structures of zinc-dependent deaminases.

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Conticello, S., Langlois, MA. & Neuberger, M. Insights into DNA deaminases. Nat Struct Mol Biol 14, 7–9 (2007). https://doi.org/10.1038/nsmb0107-7

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