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The molecular basis of metabolic cycles and their relationship to circadian rhythms

Nature Structural & Molecular Biology volume 23, pages 1035–1044 (2016)Cite this article

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Abstract

Metabolic cycles result from the partitioning of oxidative and reductive metabolism into rhythmic phases of gene expression and oscillating post-translational protein modifications. Relatively little is known about how these switches in gene expression are controlled, although recent studies have suggested that transcription itself may play a central role. This review explores the molecular basis of the metabolic and gene-expression oscillations in the yeast Saccharomyces cerevisiae, as well as how they relate to other biological time-keeping mechanisms, such as circadian rhythms.

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Figure 1: Factors that contribute to biological rhythms and cycles.
Figure 2: Metabolic cycles in S. cerevisiae. (a) Cycling metabolites during the YMC.
Figure 3: Coupling of growth rate, metabolic cycling, the CDC and gene expression.
Figure 4: Transcriptional-state-switching at YMC-regulated genes.

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Acknowledgements

This work was funded by the BBSRC (BB/J0054X/1), the Wellcome Trust (089156) and EC FP7 EpiGeneSys. Many thanks to F. Howe, R. Woloszczuk, A. Angel and all members of J.M.'s laboratory.

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  1. Department of Biochemistry, University of Oxford, Oxford, UK

    Jane Mellor

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Correspondence to Jane Mellor.

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J.M. acts as an advisor to, and holds stock in, Oxford Biodynamics Ltd., Chronos Therapeutics Ltd. and Sibelius Ltd.

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Mellor, J. The molecular basis of metabolic cycles and their relationship to circadian rhythms. Nat Struct Mol Biol 23, 1035–1044 (2016). https://doi.org/10.1038/nsmb.3311

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