Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Year in Review
  • Published:

UTUC in 2017

Emerging evidence on treating upper tract urothelial cancer

Major advances in the management of all stages of upper tract urothelial carcinoma have been made in 2017. Radical nephroureterectomy can be valuable in patients with metastatic disease and adjuvant platinum-based chemotherapy can improve outcomes in those with advanced disease. Kidney-sparing surgery with early follow-up ureterorenoscopy has shown benefit in patients with low-grade tumours. Avoiding unnecessary ureterorenoscopy might decrease intravesical tumour recurrence.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Rouprêt, M. et al. European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2017 Update. Eur. Urol. http://dx.doi.org/10.1016/j.eururo.2017.07.036 (2017).

  2. Seisen, T. et al. Efficacy of Systemic Chemotherapy Plus Radical Nephroureterectomy for Metastatic Upper Tract Urothelial Carcinoma. Eur. Urol. 71, 714–718 (2017).

    Article  Google Scholar 

  3. Seisen, T. et al. Effectiveness of adjuvant chemotherapy after radical nephroureterectomy for locally advanced and/or positive regional lymph node upper tract urothelial carcinoma. J. Clin. Oncol. 35, 852–860 (2017).

    Article  Google Scholar 

  4. Seisen, T. et al. Oncologic outcomes of kidney-sparing surgery versus radical nephroureterectomy for upper tract urothelial carcinoma: a systematic review by the EAU non-muscle invasive bladder cancer guidelines panel. Eur. Urol. 70, 1052–1068 (2016).

    Article  Google Scholar 

  5. Villa, L. et al. Early repeated ureteroscopy within 6–8 weeks after a primary endoscopic treatment in patients with upper tract urothelial cell carcinoma: preliminary findings. World J. Urol. 34, 1201–1206 (2016).

    Article  Google Scholar 

  6. Marchioni, M. et al. Impact of diagnostic ureteroscopy on intravesical recurrence in patients undergoing radical nephroureterectomy for upper tract urothelial cancer: a systematic review and meta-analysis. BJU Int. 120, 313–319 (2017).

    Article  Google Scholar 

  7. Breda, A. et al. Correlation between confocal laser endomicroscopy (Cellvizio®) and histological grading of upper tract urothelial carcinoma: a step forward for a better selection of patients suitable for conservative management. Eur. Urol. Focus http://dx.doi.org/10.1016/j.euf.2017.05.008 (2017).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Morgan Rouprêt.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Grande, P., Rouprêt, M. Emerging evidence on treating upper tract urothelial cancer. Nat Rev Urol 15, 73–74 (2018). https://doi.org/10.1038/nrurol.2017.203

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrurol.2017.203

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing