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  • Review Article
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Advances in understanding and treating premature ejaculation

Nature Reviews Urology volume 12, pages 629–640 (2015)Cite this article

Subjects

Key Points

  • Premature ejaculation is extremely prevalent and can have substantial effects on quality of life

  • In 2014, the ISSM provided standard evidence-based definitions of lifelong and acquired premature ejaculation

  • The aetiologies of lifelong and acquired premature ejaculation are different; the former suggests an underlying neurobiological functional disturbance, while the latter is more likely related to underlying medical, psychological, or interpersonal causes

  • The pathophysiological mechanisms of premature ejaculation have not yet been entirely elucidated, but 5-hydroxytryptamine, dopamine, and various hormonal factors have been suggested to have a role

  • Current treatment options include behavioural therapies, topical therapies and oral medications, such as antidepressants and phosphodiesterase-5 inhibitors

  • Modafinil, silodosin and botulinum toxin might offer potential therapeutic options in the future, but require further research

Abstract

Over the past several years, many advances have been made in our understanding of the epidemiology, pathophysiology, and management of premature ejaculation. Newly developed definitions of premature ejaculation are now available, and our perception of the classification, prevalence, aetiological factors, and treatment options for premature ejaculation have evolved. Despite ongoing research, there remains much to be learned about all aspects of this common sexual disorder, in particular effective clinical diagnosis and treatment options.

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Figure 1: The ejaculation reflex and ejaculatory control.

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Authors and Affiliations

  1. Department of Urology, Oregon Health & Science University, 3303 SW Bond Avenue, CH10U, Portland, 97239, OR, USA

    Theodore R. Saitz

  2. Department of Urology, Bagcilar Training & Research Hospital, Merkez Mahallesi Mimar Sinan Caddesi 6, Sokak, Bagcilar, Istanbul, 34200, Turkey

    Ege Can Serefoglu

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Saitz, T., Serefoglu, E. Advances in understanding and treating premature ejaculation. Nat Rev Urol 12, 629–640 (2015). https://doi.org/10.1038/nrurol.2015.252

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