Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Ethics

Investigators' interests: what should trial participants be told?

Minimizing the potential adverse effects of clinical investigators' financial conflicts of interest involves, in part, determining how much of an investigator's 'business' should be disclosed to participants in research studies. What should be disclosed and why? How will we know if disclosure matters?

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Weinfurt, K. P. et al. Disclosure of financial relationships to participants in clinical research. N. Engl. J. Med. 361, 916–921 (2009).

    Article  CAS  Google Scholar 

  2. Association of American Medical Colleges and Association of American Universities. Protecting patients, preserving integrity, advancing health: accelerating the implementation of COI policies in human subjects research. A Report of the AAMC-AAU Advisory Committee on Financial Conflicts of Interest in Human Subjects Research. (Association of American Medical Colleges, Washington, DC, 2008).

  3. Lo, B. & Field, M. J. (eds) Conflict of interest in medical research, education, and practice (The National Academies Press, Washington, DC, 2009).

    Google Scholar 

  4. Thompson, D. F. Understanding financial conflicts of interest. N. Engl. J. Med. 329, 573–576 (1993).

    Article  CAS  Google Scholar 

  5. Levinsky, N. G. Nonfinancial conflicts of interest in research. N. Engl. J. Med. 347, 759–761 (2002).

    Article  Google Scholar 

  6. Sollitto, S. et al. Intrinsic conflicts of interest in clinical research: a need for disclosure. Kennedy Inst. Ethics J. 13, 83–91 (2003).

    Article  Google Scholar 

  7. Gray, S. W., Hlubocky, F. J., Ratain, M. J. & Daugherty, C. K. Attitudes toward research participation and investigator conflicts of interest among advanced cancer patients participating in early phase clinical trials. J. Clin. Oncol. 25, 3488–3494 (2007).

    Article  Google Scholar 

  8. Elliott, K. C. Scientific judgment and the limits of conflict-of-interest policies. Account. Res. 15, 1–29 (2008).

    Article  Google Scholar 

  9. Kim, S. Y. H., Millard, R. W., Nisbet, P., Cox, C. & Caine, E. D. Potential research participants' views regarding researcher and institutional financial conflicts of interest. J. Med. Ethics 30, 73–79 (2004).

    Article  CAS  Google Scholar 

  10. Romain, P. L. Access to clinical care via clinical trials: is it ethically possible? Nat. Clin. Pract. Rheum. 4, 166–167 (2008).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Romain, P. Investigators' interests: what should trial participants be told?. Nat Rev Rheumatol 6, 70–71 (2010). https://doi.org/10.1038/nrrheum.2009.264

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2009.264

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing