Paediatric epilepsy is associated with a deficiency of trace elements, including selenium (Se), Zinc (Zn), chromium (Cr) and Iron (Fe), according to two recent studies. Such elements participate in the formation of enzymes that prevent accumulation of free radicals—an event that may lead to seizures and increase the risk of seizure recurrence. Seven et al. examined serum levels of trace elements in 70 patients with idiopathic intractable epilepsy and 60 healthy children. Patients had significantly lower levels of serum Se and Zn than did healthy controls. Wojciak et al. observed a reduction of serum Zn and Cr concentrations in all 23 paediatric patients examined, together with low levels of Fe in female patients. Such findings provide insight into the aetiology of paediatric epilepsy, and indicate a need for trace-element monitoring in this disorder.
ORIGINAL RESEARCH PAPERS
Seven, M. et al. Deficiency of selenium and zinc as a causative factor for idiopathic intractable epilepsy. Epilepsy Res. doi:10.1016/j.eplepsyres.2012.09.013
Wojciak, R. W. et al. The serum, zinc, copper, iron and chromium concentrations in epileptic children. Epilepsy Res. doi:10.1016/j.eplepsyres.2012.09.009
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Low levels of trace elements found in paediatric epilepsy. Nat Rev Neurol 8, 660 (2012). https://doi.org/10.1038/nrneurol.2012.239
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DOI: https://doi.org/10.1038/nrneurol.2012.239