As a close correlation exists between collagen-linked fluorescence and advanced glycation end product (AGE) content in skin biopsies, measuring skin autofluorescence (SAF) can be used to assess tissue deposition of AGEs. McIntyre et al. now report that increased SAF is independently associated with multiple cardiovascular and renal risk factors in patients with stage 3 chronic kidney disease, and may therefore be a useful and noninvasive method for assessing risk.