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A brief history of T cell help to B cells

Nature Reviews Immunology volume 15, pages 185–189 (2015)Cite this article

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Abstract

In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4+ T cells that constitute 'help' to B cells, and particularly the molecules expressed by T follicular helper (TFH) cells, which are the specialized providers of help to B cells.

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Figure 1: A timeline of discoveries about T cell help to B cells.
Figure 2: Categories of T cell help to B cells.

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  1. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, San Diego, 92037, California, USA

    Shane Crotty

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Correspondence to Shane Crotty.

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Crotty, S. A brief history of T cell help to B cells. Nat Rev Immunol 15, 185–189 (2015). https://doi.org/10.1038/nri3803

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