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Diabetes

Unravelling the enigma of T2DM and cardiovascular disease

The association of type 2 diabetes mellitus with an increased risk of cardiovascular disease has been extensively documented, but the origins of this association remain largely in the realm of hypotheses. With surprisingly few insights into mechanisms of increased cardiovascular disease risk, efforts to shed new light on this important question are welcome.

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References

  1. Stern, M. P. Diabetes and cardiovascular disease. The “common soil” hypothesis. Diabetes 44, 369–374 (1995).

    Article  CAS  PubMed  Google Scholar 

  2. Qi, L. et al. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA 310, 821–828 (2013).

    Article  CAS  PubMed  Google Scholar 

  3. Qi, L. et al. Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies. J. Am. Coll. Cardiol. 58, 2675–2682 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Doria, A. et al. Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes. JAMA 300, 2389–2397 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rayner, N. W. et al. SNPs in ADAMTS7, the 9p21 region and UBE2E interact with type 2 diabetes status to modify the risk of coronary artery disease [abstract 116-LB]. Diabetes 62 (Suppl. 1A), LB32 (2013).

    Google Scholar 

  6. Go, A. S. et al. Heart disease and stroke statistics—2013 update. A report from the American Heart Association. Circulation 127, e6–e245 (2013).

    PubMed  Google Scholar 

  7. Bowden, D. W. et al. Genetic epidemiology of subclinical cardiovascular disease in the Diabetes Heart Study. Ann. Hum. Genet. 72, 598–610 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kramer, C. K. et al. Coronary artery calcium score prediction of all cause mortality and cardiovascular events in people with type 2 diabetes: systematic review and meta-analysis. BMJ 346, f1654 (2013).

    Article  PubMed  Google Scholar 

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Correspondence to Donald W. Bowden.

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Bowden, D., Cox, A. Unravelling the enigma of T2DM and cardiovascular disease. Nat Rev Endocrinol 9, 632–633 (2013). https://doi.org/10.1038/nrendo.2013.192

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