Intensive insulin therapy is extensively used to lower blood glucose concentrations in critically ill patients hospitalized within the intensive care unit. The discovery by the NICE-SUGAR study investigators that tight glucose control in this setting might actually increase mortality has generated considerable discussion about the wisdom of this approach.
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Glycemic variability and glucose complexity in critically ill patients: a retrospective analysis of continuous glucose monitoring data
Critical Care Open Access 02 October 2012
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Sacks, D. Intensive glucose control in the ICU: is SUGAR NICE?. Nat Rev Endocrinol 5, 473–474 (2009). https://doi.org/10.1038/nrendo.2009.156
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DOI: https://doi.org/10.1038/nrendo.2009.156
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