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Genetics

How to validate a breast cancer prognostic signature

Nature Reviews Clinical Oncology volume 7, pages 615–616 (2010)Cite this article

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Whether a 70-gene signature could help individualize therapy in breast cancer patients with small tumors is the subject of a recently reported study. The authors of the article raise important issues about how to validate the clinical utility of the new molecular classifiers for risk prediction.

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Authors and Affiliations

  1. Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK

    Paul D. Pharoah

  2. Department of Oncology, University of Cambridge, Cambridge Research Institute, Li Ka Shing Center, Robinson Way, Cambridge, CB2 0RE, UK

    Carlos Caldas

Authors
  1. Paul D. Pharoah
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  2. Carlos Caldas
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Correspondence to Carlos Caldas.

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The authors declare no competing financial interests.

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Pharoah, P., Caldas, C. How to validate a breast cancer prognostic signature. Nat Rev Clin Oncol 7, 615–616 (2010). https://doi.org/10.1038/nrclinonc.2010.142

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