Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Pure spillover transmission between neurons

Szapiro and Barbour describe a new mode of neuron-to-neuron communication mediated solely by spillover of neurotransmitter that diffuses out of the synaptic cleft to bind more distant receptors on postsynaptic neurons.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Pure spillover transmission between climbing fibers and molecular layer interneurons in the cerebellum.

References

  1. Eccles, J.C., Llinas, R. & Sasaki, K. Exp. Brain Res. 1, 1–16 (1966).

    Article  CAS  Google Scholar 

  2. Jorntell, H. & Ekerot, C.F. J. Neurosci. 23, 9620–9631 (2003).

    Article  Google Scholar 

  3. Scheibel, M.E. & Scheibel, A.B. J. Comp. Neurol. 101, 733–763 (1954).

    Article  CAS  Google Scholar 

  4. Palay, S. & Chan-Palay, V. Cerebellar Cortex: Cytology and Organization (Springer, New York, 1974).

    Book  Google Scholar 

  5. Sugihara, I., Wu, H. & Shinoda, Y. J. Comp. Neurol. 414, 131–148 (1999).

    Article  CAS  Google Scholar 

  6. Hamori, J. & Szentagothai, J. Brain Res. 186, 454–457 (1980).

    Article  CAS  Google Scholar 

  7. Kollo, M., Holderith, N.B. & Nusser, Z. J. Neurosci. 26, 2684–2691 (2006).

    Article  CAS  Google Scholar 

  8. Szapiro, G. & Barbour, B. Nat. Neurosci. 10, 735–742 (2007).

    Article  CAS  Google Scholar 

  9. Wadiche, J.I. & Jahr, C.E. Neuron 32, 301–313 (2001).

    Article  CAS  Google Scholar 

  10. Matsui, K. & Jahr, C.E. Neuron 40, 1173–1183 (2003).

    Article  CAS  Google Scholar 

  11. Rossi, D.J. & Hamann, M. Neuron 20, 783–795 (1998).

    Article  CAS  Google Scholar 

  12. DiGregorio, D.A., Nusser, Z. & Silver, R.A. Neuron 35, 521–533 (2002).

    Article  CAS  Google Scholar 

  13. Rancillac, A. & Crepel, F. J. Physiol. (Lond.) 554, 707–720 (2004).

    Article  CAS  Google Scholar 

  14. Smith, S.L. & Otis, T.S. Proc. Natl. Acad. Sci. USA 102, 14901–14906 (2005).

    Article  CAS  Google Scholar 

  15. Jorntell, H. & Ekerot, C.F. Neuron 34, 797–806 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nishiyama, H., Linden, D. Pure spillover transmission between neurons. Nat Neurosci 10, 675–677 (2007). https://doi.org/10.1038/nn0607-675

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0607-675

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing