Activation of G protein–coupled receptors can inhibit secretion of neurotransmittters and hormones. Two recent reports in Nature Neuroscience show that this inhibition is due to Gβγ binding to SNAP-25, directly blocking the vesicle fusion machinery.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hille, B. Trends Neurosci. 17, 531–536 (1994).
Miller, R.J. Annu. Rev. Pharmacol. Toxicol. 38, 201–227 (1998).
Scanziani, M., Salin, P.A., Vogt, K.E., Malenka, R.C. & Nicoll, R.A. Nature 385, 630–634 (1997).
Thompson, S.M., Capogna, M. & Scanziani, M. Trends Neurosci. 16, 222–226 (1993).
Blackmer, T. et al. Science 292, 293–297 (2001).
Blackmer, T. et al. Nat. Neurosci. 8, 421–425 (2005).
Gerachshenko, T. et al. Nat. Neurosci. 8, 597–605 (2005).
Gerona, R.R., Larsen, E.C., Kowalchyk, J.A. & Martin, T.F. J. Biol. Chem. 275, 6328–6336 (2000).
Zhang, X., Kim-Miller, M.J., Fukuda, M., Kowalchyk, J.A. & Martin, T.F. Neuron 34, 599–611 (2002).
Capogna, M., McKinney, R.A., O'Connor, V., Gahwiler, B.H. & Thompson, S.M. J. Neurosci. 17, 7190–7202 (1997).
Geppert, M. et al. Cell 79, 717–727 (1994).
Marek, K.W. & Davis, G.W. Neuron 36, 805–813 (2002).
Yoshihara, M. & Littleton, J.T. Neuron 36, 897–908 (2002).
Zucker, R.S. Neuron 45, 482–484 (2005).
Takahashi, M., Freed, R., Blackmer, T. & Alford, S. J. Physiol. (Lond.) 532, 323–336 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sullivan, J. Finding the G spot on fusion machinery. Nat Neurosci 8, 542–544 (2005). https://doi.org/10.1038/nn0505-542
Issue Date:
DOI: https://doi.org/10.1038/nn0505-542