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A silver lining to stroke: does ischemia generate new cortical interneurons?

Nature Neuroscience volume 13, pages 145–146 (2010)Cite this article

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New work identifies a latent population of neuronal progenitor cells in neocortical layer 1 of adult rats. These cells proliferate in response to forebrain ischemia, then integrate into the cortical network as interneurons.

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Figure 1: Transient ischemia stimulates proliferation and migration of interneuron precursors in the subpial region of the neocortex.

References

  1. Sanai, N. et al. Nature 427, 740–744 (2004).

    Article  CAS  Google Scholar 

  2. Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z. & Lindvall, O. Nat. Med. 8, 963–970 (2002).

    Article  CAS  Google Scholar 

  3. Parent, J.M. et al. J. Neurosci. 17, 3727–3738 (1997).

    Article  CAS  Google Scholar 

  4. Chen, J., Magavi, S.S. & Macklis, J.D. Proc. Natl. Acad. Sci. USA 101, 16357–16362 (2004).

    Article  CAS  Google Scholar 

  5. Ohira, K. et al. Nat Neurosci. 13, 173–179 (2010).

    Article  CAS  Google Scholar 

  6. Cobos, I., Long, J.E., Thwin, M.T. & Rubenstein, J.L. Cereb. Cortex 16, i82–i88 (2006).

    Article  Google Scholar 

  7. Batista-Brito, R. & Fishell, G. Curr. Top. Dev. Biol. 87, 81–118 (2009).

    Article  Google Scholar 

  8. Rakic, S. & Zecevic, N. Cereb. Cortex 13, 1072–1083 (2003).

    Article  Google Scholar 

  9. Wichterle, H., Garcia-Verdugo, J.M., Herrera, D.G. & Alvarez-Buylla, A. Nat. Neurosci. 2, 461–466 (1999).

    Article  CAS  Google Scholar 

  10. Zhao, J.W., Raha-Chowdhury, R., Fawcett, J.W. & Watts, C. Eur. J. Neurosci. 29, 1853–1869 (2009).

    Article  Google Scholar 

  11. Nishiyama, A. & Komitova, M. Nat. Rev. Neurosci. 10, 9–22 (2009).

    Article  CAS  Google Scholar 

  12. Yan, Y.P. et al. J. Cereb. Blood Flow Metab. 27, 1213–1224 (2007).

    Article  CAS  Google Scholar 

  13. Burkhalter, A. et al. Nat. Rev. Neurosci. 9, 557–568 (2008).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Gord Fishell is in the Department of Cell Biology and the Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, New York, New York, USA,

    Gord Fishell

  2. James E. Goldman is in the Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York, USA.,

    James E Goldman

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  1. Gord Fishell
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  2. James E Goldman
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Correspondence to Gord Fishell or James E Goldman.

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Fishell, G., Goldman, J. A silver lining to stroke: does ischemia generate new cortical interneurons?. Nat Neurosci 13, 145–146 (2010). https://doi.org/10.1038/nn0210-145

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