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Another BOLD role for astrocytes: coupling blood flow to neural activity

Nature Neuroscience volume 9, pages 159–161 (2006)Cite this article

Increased local blood flow in response to neural activity is critical for brain function and the basis for functional imaging. Takano et al. now show that in vivo, astrocytes are central in translating neural activity into vasodilation via a mechanism involving COX1 metabolites.

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Figure 1: Astrocytes couple increased local blood flow to neuronal activity.

References

  1. Iadecola, C. Nat. Rev. Neurosci. 5, 347–360 (2004).

    Article  CAS  Google Scholar 

  2. Vavilava, M.S., Lee, L.A. & Lam, A.M. Anesthesiol. Clin. North America 20, 247–264 (2002).

    Article  Google Scholar 

  3. Attwell, D. & Iadecola, C. Trends Neurosci. 25, 621–625 (2002).

    Article  CAS  Google Scholar 

  4. Takano, T. et al. Nat. Neurosci. 9, 260–267 (2006).

    Article  CAS  Google Scholar 

  5. Simard, M., Arcuino, G. Takano, T., Liu, O.S. & Nedergaard, M. J. Neurosci. 23, 9254–9262 (2003).

    Article  CAS  Google Scholar 

  6. Ventura, R. & Harris, K.M. J. Neurosci. 19, 6897–6907 (1999).

    Article  CAS  Google Scholar 

  7. Haydon, P.G. Nat. Rev. Neurosci. 2, 185–193 (2001).

    Article  CAS  Google Scholar 

  8. Zonta, M. et al. Nat. Neurosci. 6, 43–50 (2003).

    Article  CAS  Google Scholar 

  9. Pellerin, P.J. & Magistretti, J. J. Cereb. Blood Flow Metab. 23, 1282–1286 (2003).

    Article  Google Scholar 

  10. Kasischke, K.A., Vishwasrao, H.D., Fischer, P.J., Zipfel, W.R. & Webb, W.W. Science 305, 99–106 (2004).

    Article  CAS  Google Scholar 

  11. Mulligan, S.J. & MacVicar, B.A. Nature 431, 195–199 (2004).

    Article  CAS  Google Scholar 

  12. Peppiatt, C. & Attwell, D. Nature 431, 137–138 (2004).

    Article  CAS  Google Scholar 

  13. Gordon, E.L., Meno, J.R., Ngai, A.C., Lam, A.M. & Winn, H.R. J. Neurosurg. 83, 875–877 (1995).

    Article  CAS  Google Scholar 

  14. Pascual, O. et al. Science 310, 113–116 (2005).

    Article  CAS  Google Scholar 

  15. Cohen, Z., Molinatti, G. & Hamel, E. J. Cereb. Blood Flow Metab. 17, 894–904 (1997).

    Article  CAS  Google Scholar 

Download references

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  1. Neurological Sciences Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, 97006, Oregon, USA

    David J Rossi

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  1. David J Rossi
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Rossi, D. Another BOLD role for astrocytes: coupling blood flow to neural activity. Nat Neurosci 9, 159–161 (2006). https://doi.org/10.1038/nn0206-159

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