Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Watching and weighting—chaperone complexes in action

Mass spectrometry is reaching new heights monitoring changes in protein folding that occur as a result of a phage infection that commandeers the host's protein-folding machinery.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Electrospray mass spectrometry analysis reveals the dynamics of chaperon-assisted protein folding.

References

  1. van Duijn, E. et al. Nat. Methods 2, 371–376 (2005).

    Article  CAS  Google Scholar 

  2. Hohn, T., Hohn, B., Engel, A., Wurtz, M. & Smith, P.R. J. Mol. Biol. 129, 359–373 (1979).

    Article  CAS  Google Scholar 

  3. Fenn, J.B., Mann, M., Meng, C.K., Wong, S.F. & Whitehouse, C.M. Science 246, 64–71 (1989).

    Article  CAS  Google Scholar 

  4. Robinson, C.V. et al. Nature 372, 646–651 (1994).

    Article  CAS  Google Scholar 

  5. Rostom, A.A. & Robinson, C.V. J. Am. Chem. Soc. 121, 4718–4719 (1999).

    Article  CAS  Google Scholar 

  6. Sobott, F. & Robinson, C.V. Int. J. Mass Spectrom. 236, 25–32 (2004).

    Article  CAS  Google Scholar 

  7. Aebersold, R. & Mann, M. Nature 422, 198–207 (2003).

    Article  CAS  Google Scholar 

  8. Xu, Z., Horwich, A.L. & Sigler, P.B. Nature 388, 741–750 (1997).

    Article  CAS  Google Scholar 

  9. Ranson, N.A. et al. Cell 107, 869–879 (2001).

    Article  CAS  Google Scholar 

  10. Fiaux, J., Bertelsen, E.B., Horwich, A.L. & Wuthrich, K. Nature 418, 207–211 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Robinson, C. Watching and weighting—chaperone complexes in action. Nat Methods 2, 331–332 (2005). https://doi.org/10.1038/nmeth0505-331

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth0505-331

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing