Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Shedding light on G protein–coupled receptor signaling

Nature Methods volume 9, pages 965–966 (2012)Cite this article

Subjects

A new high-throughput method for monitoring G protein–coupled receptor activation is highly suited to assaying Gα12/13-coupled receptors and is used to deorphanize a group of receptors activated by lysophosphatidylserine.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The TGF-α shedding assay.

Debbie Maizels

References

  1. Inoue, A. et al. Nat. Methods 9, 1021–1029 (2012).

    Article  CAS  Google Scholar 

  2. Fredriksson, R. & Schiöth, H.B. Mol. Pharmacol. 67, 1414–1425 (2005).

    Article  CAS  Google Scholar 

  3. Jacoby, E. et al. ChemMedChem 1, 761–782 (2006).

    Article  Google Scholar 

  4. Thomsen, W., Frazer, J. & Unett, D. Curr. Opin. Biotechnol. 16, 655–665 (2005).

    CAS  Google Scholar 

  5. Barnea, G et al. Proc. Natl. Acad. Sci. USA 105, 64–69 (2008).

    Article  CAS  Google Scholar 

  6. Zhang, J.H., Chung, T.D. & Oldenburg, K.R. J. Biomol. Screen. 4, 67–73 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Marc Parmentier is at the Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Université Libre de Bruxelles, Campus Erasme, Brussels, Belgium.,

    Marc Parmentier

Authors
  1. Marc Parmentier
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marc Parmentier.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Parmentier, M. Shedding light on G protein–coupled receptor signaling. Nat Methods 9, 965–966 (2012). https://doi.org/10.1038/nmeth.2178

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.2178

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing