Abstract
Results from the Diabetes Care and Complications Trial show that tight blood glucose control significantly reduces the long-term complications of diabetes mellitus1. In that study, frequent self-testing of glucose and insulin administration resulted in a significant reduction in long-term complications. This protocol, however, also resulted in a threefold increase in the frequency of hypoglycaemic incidents. Currently, self-testing requires a drop of blood for each measurement. The pain and inconvenience of self-testing, along with the fear and danger of hypoglycaemia has led to poor patient acceptance of a tight control regimen, despite the clear long-term advantages. A continuously worn, noninvasive method to periodically measure glucose would provide a convenient and comfortable means of frequent self-testing2,3. A continuously worn device could also alert the user of low glucose levels, thereby reducing the incidence of hypoglycaemia4,5. Guy et al. demonstrated a noninvasive method to transport glucose through the skin using low-level electrical current6,7. To provide a quantitative measurement, the flux of glucose extracted across the skin must correlate with serum glucose in a predictive manner. The results presented here show a quantitative relationship between serum and transdermally extracted glucose in diabetics.
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References
The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New. Engl. J. Med. 329, 977–1036 (1993).
Meyerhoff, C., Bischof, F., Sternberg, F., Zier, H. & Pfeiffer, E.F. . On line continuous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis. Diabetologia 35, 1087–1092 (1992).
Moatti-Sirat, D. et al. Towards continuous glucose monitoring: In vivo evaluation of miniaturized glucose sensor implanted for several days in rat subcutaneous tissue. Diabetologia 35, 224–230 (1992).
Reach, G. & Wilson, G. Can continuous glucose monitoring be used for the treatment of diabetes? Analyt. Chem. 64, 381–386 (1992).
Reach, G. Continuous glucose monitoring with a subcutaneous sensor. Rationale, requirements and achievements, and prospects. in The Diabetes Annual (eds Alberti, K.G.M.M. & Home, P.D.) 332–348 (Elsevier, New York, 1993).
Glikfeld, P., Hinz, R.S. & Guy, R.H. Noninvasive sampling of biological fluids by iontophoresis. Pharmac. Res. 6, 988–990 (1989).
Rao, G. et al. Reverse iontophoresis: Noninvasive glucose monitoring in vivo in humans. Pharmac. Res. (in the press).
Clarke, W.L., Cox, D.C., Conder-Frederick, L.A., Carter, W. & Pohl, S.L. Evaluating clinical accuracy of systems for self-monitoring of blood glucose. Diabetes Care 10, 622–628 (1987).
O'Shea, T.J., Lunte, S.M. & LaCourse, W.R. Detection of carbohydrates by capillary electrophoresis with pulsed amperometric detection. Analyt. Chem. 64, 381–386 (1992).
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Tamada, J., Bohannon, N. & Potts, R. Measurement of glucose in diabetic subjects using noninvasive transdermal extraction. Nat Med 1, 1198–1201 (1995). https://doi.org/10.1038/nm1195-1198
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DOI: https://doi.org/10.1038/nm1195-1198
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